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Project Artichoke: 70 Years Ago, CIA Discussed Hiding Mind-Control Drugs in Vaccines

By Michael Nevradakis, Ph.D. | The Defender | February 24, 2026

In the 1950s, the CIA brainstormed ways to secretly perform mind control on humans — including concealing drugs in vaccines and widely consumed food products, a newly unearthed CIA document revealed. The Daily Mail first reported the story on Monday.

The seven-page document, “Special Research for Artichoke,” is dated April 23, 1952. It describes a series of ideas for how to develop chemicals designed to alter human behavior and thought.

The proposals contained in the document were part of the CIA’s top-secret Project Artichoke, which ran from 1951 to 1956, according to the Daily Mail.

The document, declassified in 1983, recently circulated on social media. However, it was not published in the CIA’s online reading room until last year.

“Some of the suggestions are controversial,” the document states. The proposals included administering drugs in secret as part of a “long-range approach to subjects.”

According to the document:

“This study should include chemicals or drugs that can effectively be concealed in common items such as food, water, coca cola, beer, liquor, cigarettes, etc.

“This type of drug should also be capable of use in standard medical treatments such as vaccinations, shots, etc.”

CIA experimented on humans as part of Project Artichoke

The document also included a special field of research for “bacteria, plant cultures, fungi, poisons of various types, etc.,” that are “capable of producing illnesses which in turn would produce high fevers, delirium, etc.”

This included “species of the mushroom” that “produce a certain type of intoxication and mental derangement.”

Also among the proposals was a suggestion to research “diet” or “dietary deficiencies” on prisoners and on people undergoing interrogation, including using “specially canned foods having elements removed.”

The document included proposals for both short-term and long-term use on humans. Drugs deemed most suitable for long-term use would be designed to produce an “agitating effect (producing anxiety, nervousness, tension, etc.) or a depressing effect (creating a feeling of despondency, hopelessness, lethargy, etc.).”

According to The Daily Mail, the CIA experimented on humans as part of Project Artichoke. The experiments often involved “vulnerable subjects, including prisoners, military personnel and psychiatric patients.” The experiments were usually performed “without informed consent.”

According to Ben Tapper, a Nebraska chiropractor who was included in the “Disinformation Dozen” list in 2021 for questioning vaccine safety, the document exposes “a disturbing reality that government agencies have historically explored ways to manipulate human behavior through chemical and biological means, including concepts involving food and medical interventions.”

“This is not speculation or conspiracy, and it should deeply concern every American who values bodily autonomy and informed consent,” Tapper said.

Precursor to the CIA’s MK-Ultra mind control experiments?

The Daily Mail cited CIA documents suggesting that U.S. intelligence agencies were concerned that enemy nations had developed their own mind and behavioral control techniques. This led the agency to prioritize the development of its own methods.

Project Artichoke “served as a precursor” to the MK-Ultra program, which the CIA launched in 1953. That program “broadened mind-altering experiments on a larger scale,” the Daily Mail reported.

Many of the documents related to this type of experimentation were destroyed in 1973, “leaving the full extent of the research and how far it progressed unknown.”

Naomi Wolf, Ph.D., CEO of Daily Clout and author of “The Pfizer Papers: Pfizer’s Crimes Against Humanity,” told The Defender that the documents further confirm a long history of intelligence agency research targeting human thought and behavior.

“Sadly, it’s long been established that our intelligence agencies, and those of our enemies, have sought to alter human consciousness and behavior, often without the subjects’ consent. The existence of MK-Ultra, the clandestine project into which Project Artichoke evolved, is well documented,” Wolf said.

John Leake, vice president of the McCullough Foundation and author of the forthcoming book, “Mind Viruses: America’s Irrational Obsessions,” said, “Researchers have long suspected that the Church Committee’s revelation of the CIA’s notorious MK-Ultra mind control experiments, mostly using LSD, had the effect of obscuring the agency’s much larger Project Artichoke.”

Leake cited evidence suggesting that a 1951 mass poisoning in Pont-Saint-Esprit, France, in which 250 residents experienced severe hallucinations and seven people died, was a Project Artichoke experiment. The outbreak was officially attributed to contaminated bread from a local bakery.

Leake said the 1952 document is “consistent with the suspicion that the CIA was seeking to discover mind control methods for even large populations.”

In 2024, a Reuters investigation revealed that the CIA operated a secret propaganda campaign involving vaccines in the Philippines. The campaign attacked what the agency perceived as China’s “growing influence” in the country by targeting the Chinese-made Sinovac COVID-19 vaccine through the use of phony online accounts spreading “anti-vax” messaging.

Michael Rectenwald, Ph.D., author of “The Great Reset and the Struggle for Liberty: Unraveling the Global Agenda,” said the Project Artichoke revelations “make it clear that the CIA has posed an enormous threat to U.S. citizens, in addition to the horrors it unleashes on non-U.S. target governments and populations.”

Project Artichoke wanted to enlist help from Army’s Chemical Warfare Service

The 1952 Project Artichoke document also included a recommendation to involve the U.S. Army Chemical Warfare Service in the project’s efforts, citing its experience with “exhaustive studies along these lines.”

This proposal bears a resemblance to recent suggestions that COVID-19 — and the response to the pandemic — were coordinated at high levels of government, military and intelligence agencies.

Last year, former pharmaceutical research and development executive Sasha Latypova and retired science writer Debbie Lerman released the “Covid Dossier,” presenting evidence of the “military/intelligence coordination of the Covid biodefense response in the US, UK, Australia, Canada, the Netherlands, Germany, and Italy.”

According to Latypova and Lerman, “Covid was not a public health event” but “a global operation, coordinated through public-private intelligence and military alliances and invoking laws designed for CBRN (chemical, biological, radiological, nuclear) weapons attacks.”

Leake said “it is far from clear” that the Church Committee hearings of 1975 “put a complete end to CIA covert programs.” He cited the possible laboratory development of the SARS-CoV-2 virus as an example.

“The laboratory creation of SARS-CoV-2 with gain-of-function techniques developed at the University of North Carolina-Chapel Hill, and the U.S. military’s involvement in developing and distributing of mRNA COVID-19 vaccines, should … be regarded as possible outgrowths or even continuations of Project Artichoke,” Leake said.

Experts question similarities between Project Artichoke, COVID vaccines

In a Substack post today, epidemiologist Nicolas Hulscher drew a potential connection between Project Artichoke and the development of COVID-19 vaccines. Hulscher cited recent peer-reviewed studies that identified the vaccines’ adverse impact on neurological health and “surging rates of cognitive decline.”

Hulscher wrote:

“Disturbingly, since 2021, over 70% of humanity received a neurotoxic agent masquerading as a ‘vaccine.’ The same goals outlined in the CIA document (vaccines/drugs capable of covertly inducing anxiety, depression, and lethargy) are now being observed in COVID-19 vaccinated populations. …

“… If the CIA was secretly discussing covert methods to alter human behavior in the 1950s, it would be no surprise if similar classified projects emerged in the decades that followed.”

A 2024 paper published in the journal Molecular Psychiatry investigated psychiatric adverse events among over 2 million people in South Korea. The study found that “COVID-19 vaccination increased the risks of depression, anxiety, dissociative, stress-related, and somatoform disorders, and sleep disorders while reducing the risk of schizophrenia and bipolar disorder.”

A 2025 study published in the International Journal of Innovative Research in Medical Science found “alarming safety signals regarding neuropsychiatric conditions following COVID-19 vaccination, compared to the influenza vaccinations and to all other vaccinations combined.”

This included increases in schizophrenia, depression, cognitive decline, delusions, violent behavior, suicidal thoughts and homicidal ideation.

“The fact that mRNA vaccines were designed to cross the blood-brain barrier and inflame the brain — or at least, they were known to do so, during their manufacture and distribution — should give us pause in light of this news,” Wolf said.

Wolf said the latest revelations, “while shocking, provide all the more reason for us to be critical of opaque, coercive or untested vaccination programs, additives in food and water, and toxic or opaque geoengineering programs.”

Tapper said the revelations reinforce “the urgent need to protect individual liberty, medical freedom, and ethical boundaries in science and public health.”

“The lesson here is simple: vigilance is necessary when governments claim authority over the human body and mind,” Tapper said.

This article was originally published by The Defender — Children’s Health Defense’s News & Views Website under Creative Commons license CC BY-NC-ND 4.0. Please consider subscribing to The Defender or donating to Children’s Health Defense.

February 24, 2026 Posted by | Civil Liberties, Deception, Full Spectrum Dominance | , , , , , , , , , , , | Comments Off on Project Artichoke: 70 Years Ago, CIA Discussed Hiding Mind-Control Drugs in Vaccines