Vitamin D reduced dementia by 40%

Dr John Campbell | March 13, 2023

Mosquito net distribution in Uganda, donations to this project, https://www.buymeacoffee.com/awmedica…

More videos from this project, https://www.youtube.com/channel/UCzsL…

Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status https://alz-journals.onlinelibrary.wi…

Alberta, Canada Known association, vitamin D deficiency, incident dementia https://nutritionj.biomedcentral.com/…

Role of supplementation is unclear. Prospectively study Associations, vitamin D supplementation and incident dementia N = 12,388 dementia-free people (from the National Alzheimer’s Coordinating Center)

Methods Baseline exposure to vitamin D was considered D+ No exposure prior to dementia onset was considered D− MCI and depression were both more frequent in the D− group, compared to D+ People taking vitamin D had less MCI and less depression

Adjusted for age, sex, education, race, cognitive diagnosis, depression, and apolipoprotein E (APOE) ε4. Potential interactions between exposure and model covariates were explored. Results Across all formulations, vitamin D exposure was associated with significantly longer dementia-free survival, and lower dementia incidence rate than no exposure

Hazard ratio = 0.60 (95% confidence interval: 0.55–0.65) Vitamin D exposure was associated with 40% lower dementia incidence versus no exposure. Over 10 year follow up of 12,388 2,696 participants progressed to dementia

Among them the 2,696 2,017 (74.8%) had no exposure to vitamin D 679 (25.2%) had baseline exposure

Exposure to vitamin D was associated with significantly higher dementia-free survival 5-year survival for D− was 68.4% 5-year survival for D+ was 83.6%

The effect of vitamin D on incidence rate differed significantly, Vitamin D effects were significantly greater in females versus males

Vitamin D effects were significantly greater in normal cognition versus mild cognitive impairment.

Vitamin D effects were significantly greater in apolipoprotein E ε4 non-carriers versus carriers.

Vitamin D effects were less significantly apolipoprotein E ε4 carriers. (25% one copy, 3% two copies)

Vitamin D has potential for dementia prevention, especially in the high-risk strata.

Vitamin D deficiency, worldwide prevalence of up to 1 billion. https://www.sciencedirect.com/science…

Mechanism of action https://www.nature.com/articles/s4143…

Vitamin D is known to participate in the clearance of amyloid beta (Aβ) aggregates, one of the hallmarks of Alzheimer’s disease (AD), and may provide neuroprotection against Aβ-induced tau hyperphosphorylation (neurofibrillary tangles) Cholecalciferol may be more effective than ergocalciferol

March 16, 2023 - Posted by aletho | Science and Pseudo-Science, Timeless or most popular, Video

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A superpower and “the world’s sickest warrior state”

By Paul J. Balles | March 8, 2010

Living through five or six major wars has hardened me to what I thought were the extremes of inhuman cruelty and brutality.

Two things made those extremes almost bearable: the brutality always revealed – at least according to the media coverage – the viciousness of the enemy. It was therefore quite understandable when our “brave men and women” pulverized the enemy.

Films of Japanese torturing captive Americans somehow justified holding Japanese Americans in internment camps during World War II; and only a small percentage of Americans found the bombing of Hiroshima and Nagasaki unreasonably vengeful at best, at worst, depraved.

The media giants in America portrayed the North Koreans as barbaric beasts with their captives, quite unlike their southern counterpoints – our allies during the Korean War. No one ever felt the need to explain how the South Koreans were a civilized breed while the North Koreans were absolute savages, at least according to the official line.

In Vietnam, our warriors justifiably (or so the media made us believe) dropped napalm on the North Vietnamese who had the gall to hide in villages and tunnels to ravage our invaders. At least it was accepted practice until some rogue photojournalist filmed a young girl screaming down a Vietnamese road in flames. … continue

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