Vitamin D reduced dementia by 40%
Dr John Campbell | March 13, 2023
Mosquito net distribution in Uganda, donations to this project, https://www.buymeacoffee.com/awmedica…
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Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status https://alz-journals.onlinelibrary.wi…
Alberta, Canada Known association, vitamin D deficiency, incident dementia https://nutritionj.biomedcentral.com/…
Role of supplementation is unclear. Prospectively study Associations, vitamin D supplementation and incident dementia N = 12,388 dementia-free people (from the National Alzheimer’s Coordinating Center)
Methods Baseline exposure to vitamin D was considered D+ No exposure prior to dementia onset was considered D− MCI and depression were both more frequent in the D− group, compared to D+ People taking vitamin D had less MCI and less depression
Adjusted for age, sex, education, race, cognitive diagnosis, depression, and apolipoprotein E (APOE) ε4. Potential interactions between exposure and model covariates were explored. Results Across all formulations, vitamin D exposure was associated with significantly longer dementia-free survival, and lower dementia incidence rate than no exposure
Hazard ratio = 0.60 (95% confidence interval: 0.55–0.65) Vitamin D exposure was associated with 40% lower dementia incidence versus no exposure. Over 10 year follow up of 12,388 2,696 participants progressed to dementia
Among them the 2,696 2,017 (74.8%) had no exposure to vitamin D 679 (25.2%) had baseline exposure
Exposure to vitamin D was associated with significantly higher dementia-free survival 5-year survival for D− was 68.4% 5-year survival for D+ was 83.6%
The effect of vitamin D on incidence rate differed significantly, Vitamin D effects were significantly greater in females versus males
Vitamin D effects were significantly greater in normal cognition versus mild cognitive impairment.
Vitamin D effects were significantly greater in apolipoprotein E ε4 non-carriers versus carriers.
Vitamin D effects were less significantly apolipoprotein E ε4 carriers. (25% one copy, 3% two copies)
Vitamin D has potential for dementia prevention, especially in the high-risk strata.
Vitamin D deficiency, worldwide prevalence of up to 1 billion. https://www.sciencedirect.com/science…
Mechanism of action https://www.nature.com/articles/s4143…
Vitamin D is known to participate in the clearance of amyloid beta (Aβ) aggregates, one of the hallmarks of Alzheimer’s disease (AD), and may provide neuroprotection against Aβ-induced tau hyperphosphorylation (neurofibrillary tangles) Cholecalciferol may be more effective than ergocalciferol
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March 16, 2023 - Posted by aletho | Science and Pseudo-Science, Timeless or most popular, Video
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British Intel Tried to Make N Irish Gang ‘Shoot Up’ School, Documentary Claims
Sputnik – 23.02.2019
A new documentary, based on an interview with a self-confessed member of the Glennane Gang, gives some insights into allegations that British military intelligence was behind a shocking murder plot to cause the situation in Northern Ireland to “spiral out of control”.
In a documentary, Unquiet Graves: The Story of the Glennane Gang, John Weir, a former officer from the Royal Ulster Constabulary (RUC), alleges that British intelligence tried to persuade paramilitary group Ulster Volunteer Force (UVF) to attack a Catholic primary school at Belleeks in County Armagh.
Weir claimed that the UVF was urged to kill children and teachers in retaliation for the 1976 Kingsmill massacre, in which gunmen stopped a minibus carrying twelve workmen and shot them; only one person survived despite having been shot 18 times.
“The plan that was decided on was to shoot up a school in Belleeks”, he said, adding that the British intelligence plot was to make the situation in Northern Ireland “spiral out of control”. … continue
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