Vitamin D Cuts COVID-19 Risk of Death in Half, New Study Finds. So Why Isn’t it Recommended?
BY WILL JONES | THE DAILY SCEPTIC | FEBRUARY 3, 2023
Vitamin D cuts the risk of death from COVID-19 by 51% and the risk of ICU admission by 72%, a meta-analysis of randomised controlled trials has found. The new study, published in Pharmaceuticals, is titled “Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalisation and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis”. Here’s the abstract, summarising the study’s method and results.
Background: The COVID-19 pandemic represents one of the world’s most important challenges for global public healthcare. Various studies have found an association between severe vitamin D deficiency and COVID-19-related outcomes. Vitamin D plays a crucial role in immune function and inflammation. Recent data have suggested a protective role of vitamin D in COVID-19-related health outcomes. The purpose of this meta-analysis and trial sequential analysis (TSA) was to better explain the strength of the association between the protective role of vitamin D supplementation and the risk of mortality and admission to intensive care units (ICUs) in patients with COVID-19.
Methods: We searched four databases on September 20th 2022. Two reviewers screened the randomised clinical trials (RCTs) and assessed the risk of bias, independently and in duplicate. The pre-specified outcomes of interest were mortality and ICU admission.
Results: We identified 78 bibliographic citations. After the reviewers’ screening, only five RCTs were found to be suitable for our analysis. We performed meta-analyses and then TSAs. Vitamin D administration results in a decreased risk of death and ICU admission (standardised mean difference (95% CI): 0.49 (0.34–0.72) and 0.28 (0.20–0.39), respectively). The TSA of the protective role of vitamin D and ICU admission showed that, since the pooling of the studies reached a definite sample size, the positive association is conclusive. The TSA of the protective role of vitamin D in mortality risk showed that the z-curve was inside the alpha boundaries, indicating that the positive results need further studies.
Discussion: The results of the meta-analyses and respective TSAs suggest a definitive association between the protective role of vitamin D and ICU hospitalisation.
Despite these highly positive results, the latest official guidelines from NICE still state that vitamin D is not recommended for the prevention of COVID-19. (NICE also doesn’t recommend the use of ivermectin or budesonide.) Yet remdesivir is recommended despite the WHO finding little or no effect. Will NICE now update its guidelines? I wouldn’t count on it.
Dr. John Campbell discusses the new study in a recent video, arguing the evidence on vitamin D is now conclusive and wondering why adequate vitamin D supplementation is not being officially promoted in the U.K. The fact that the MHRA is 86% industry-funded may have something to do with it, he suggests.
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From the Archives
A low-fat, high-carb diet has been the largest public health experiment in history. It’s past time for a rethink.
By Malcolm Kendrick | RT | November 25, 2020
New research suggests that four billion people globally will be overweight in 2050. This trend can be traced back to the ‘low-fat, high-carb’ guidelines first issued in the 70s, and should prompt a major U-turn on dietary advice.
A recent report from the Potsdam Institute predicts that by 2050 there will be four billion overweight people in the world, with one-and-a-half billion of them obese. This is not entirely surprising. The world has been getting fatter for years, and things do not seem to be slowing down.
Why is this happening? … continue
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