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‘Insane’: Boston Researchers Create ‘More Lethal’ Strain of COVID, Prompting Calls to Shut Down Risky Gain-of-Function Research

By Michael Nevradakis, Ph.D. | The Defender | October 18, 2022

A team of 14 scientists at Boston University’s National Emerging Infectious Diseases Laboratories (NEIDL) developed a new strain of COVID-19 that killed 80% of the mice infected with the virus in a laboratory setting, according to a preprint study published Oct. 14.

Following the announcement, numerous news stories about the study’s results focused on the fatality rate observed in the laboratory mice used in the study.

However, behind the headlines, some scientists and others raised concerns about the nature of the research and the fact that it was partially funded by the National Institute of Allergy and Infectious Diseases (NIAID), headed by Dr. Anthony Fauci.

The research was conducted using what some scientists called “gain-of-function” research, raising concerns that this type of research — which some theorize led to the creation and escape of the original Wuhan strain of COVID-19 — is still being done, despite concerns that it could lead to more lab escapes and more pandemics.

Gain of function refers to the “manipulation of pathogens to make them more dangerous,” in the hope of “getting ahead of a future outbreak.”

Commenting on the researchers’ announcement, Robert F. Kennedy, Jr., Children’s Health Defense chairman of the board and chief legal counsel, remarked on the potential danger of such research — and its federal funding:

“What could be more insane than Anthony Fauci funding more of his GOF [gain of function] experiments to soup up coronavirus lethality in the middle of a pandemic caused by a juiced-up coronavirus that has killed millions?

“All of horrified humanity is watching Lord Of The Flies play out at NIH [National Institutes of Health] and praying for the adults to appear.”

Rachel Lapal Cavallario, Boston University’s associate vice president for public relations and social media, told the media the research conducted was not gain-of-function research and that, “In fact, this research made the virus [replication] less dangerous.”

However, others disputed that claim.

Sen. Roger Marshall (R-Kan.), a doctor, said the research involved “lethal gain of function virus research” that creates the “potential to kill more people than any singular nuclear weapon.”

“Viruses have managed to escape even the most secure labs,” Marshall said, adding that this type of “research must stop immediately while the risks and benefits can be investigated.”

Jessica Rose, Ph.D., commenting on the NEIDL research on Substack, wrote:

“What they have done in this work, as described by their own methods and results, is akin to madness.

“It is akin to madness because … they basically created and published a recipe for a deadly pathogen (80% mortality rate in the subjects of their experiments) of their own construction in their lab.

“By the way, this is precisely gain-of-function research. It couldn’t be more descriptive.”

Boston University today issued the following statement, downplaying the risks of the research:

“The research was reviewed and approved by the Institutional Biosafety Committee (IBC), which consists of scientists as well as local community members. The Boston Public Health Commission also approved the research.

“Furthermore, this research mirrors and reinforces the findings of other, similar research performed by other organizations, including the FDA. Ultimately, this research will provide a public benefit by leading to better, targeted therapeutic interventions to help fight against future pandemics.”

Efforts to prevent construction of NEIDL BSL-4 lab failed

NEIDL describes itself as “a Boston University Center dedicated to research on emerging and re-emerging infectious diseases and the pathogens that cause them,” and “a major step forward in advancing public health” that “provide[s] the necessary information and understanding to develop diagnostic tests, treatments, and vaccines.”

NEIDL also claims that it “will not conduct any secret or classified research” and that “the public will have access through several channels to information about any and all research before it even begins” — making NIAID’s claims that it was unaware of the spike protein research project all the more perplexing.

According to the Daily Mail, NEIDL is one of 13 biosafety level 4 (BSL-4) labs in the U.S.

However, this particular research took place under BSL-3 precautions, although according to STAT, “There is no evidence the work … was conducted improperly or unsafely,” noting that an internal biosafety review committee and the Boston Public Health Commission approved the work.

The journal Nature described the difference between BSL-3 and BSL-4 as follows:

“BSL-3 laboratories are designed so that scientists can safely work with potentially lethal and inhalable pathogens in a contained environment. Experiments are conducted in sealed workspaces in which the air is filtered and not recirculated, and the entrance to the facility is typically secured by self-closing doors.

“BSL-4 facilities, in which researchers work with fatal pathogens that can spread through aerosols, and for which vaccines or treatments are lacking or limited, require extra security measures.”

University of Illinois international law professor Francis Boyle, J.D., Ph.D., said the dangers of BSL-4 facilities have long been known, which is why he participated in efforts to stop the construction of the NEIDL facility.

Boyle, a bioweapons expert who drafted the Biological Weapons Anti-Terrorism Act of 1989, told The Defender:

“Years ago, there was a lawsuit to prevent and stop the building of this BSL-4 [facility] at Boston University that I did work on, and we failed.

“At that time we argued that the BSL-4 would engage in existentially type dangerous biological warfare research, and that was even before … gain-of-function.

So, we knew from the get-go how dangerous this lab was going to be and tried to stop it. We tried, we failed, and now this Nazi biowarfare death science dirty work is going on.”

However, the Boston University facility was completed with $128 million in NIH funding.

Commenting on gain-of-function research in general, Boyle said:

“You’ll note it was funded by NIH and NIAID under Tony Fauci.

“The New York Times has pointed out that about 94% of all this Nazi biowarfare death science dirty work has been funded by NIH and NIAID since Reagan put him in charge of NIAID.”

According to Boyle, this has resulted in more than $100 billion in federal bioweapons spending since Sept. 11, 2001.

Boyle said the federal government “doesn’t rein in or prosecute” scientists working on such projects, “because the federal government is paying for this type of Nazi biowarfare death science dirty work.”

Such research, and the facilities in which it is performed, also pose a risk to surrounding communities and the world at large, Boyle said, suggesting a Wuhan-like leak could occur at any similar facility in the U.S.:

“This is another catastrophe waiting to happen, and that Boston University BSL-4 [facility] should be shut down immediately.

“They know full well how existentially dangerous this is, certainly for the metropolitan Boston area … and especially for the African American community in Dorchester surrounding that Boston University BSL-4 lab.”

For Boyle, “It’s not enough to ban gain-of-function.” He also called for BSL-3 and BSL-4 facilities, including the Boston University facility, a CDC facility in Atlanta and a new facility in Kansas where the federal Plum Island Animal Disease Center is being relocated, to be shut down.

“The only remedy here is to shut down all BSL-3s and BSL4-s in the U.S.A., immediately and effectively,” Boyle said. “Otherwise, there is going to be another leak.”

Notably, the Wuhan Institute of Virology where research involving “engineered novel bat coronaviruses” took place is said to have been performed in BSL-2 and BSL-3 facilities.

Rose questioned the lower safety conditions under which the NEIDL researchers created the hybrid strain, while also raising broader security concerns and calling for gain-of-function work to be “banned” and its products “destroyed immediately.”

She said:

“This paper reveals more than the successful creation of a deadly new virus. It [gives] this recipe in the methods to anyone with a decent lab to recreate it.

“They don’t even mention what the hell they are planning to do with this new virus! They don’t say a bloody word about the fact that they created a virus that for all intents and purposes, is a Level IV pathogen, so why the hell are they playing with it in a Level III [laboratory]?”

NIH claims it didn’t know what it was funding

According to NEIDL, grants from the NIH “provide the support for research at NEIDL.”

In September, the study’s lead author, Mohsan Saeed, Ph.D., received a five-year, $2 million grant from the NIAID, and a separate five-year, $2 million grant from the National Institute of General Medical Sciences, to “explore novel aspects of clinically important viruses and human defense mechanisms.”

Nancy J. Sullivan, NEIDL’s new director previously was chief of the Biodefense Research Section at NIAID’s Vaccine Research Center.

Following the publication of the preprint study — and the controversy that ensued — the NIAID appeared to distance itself from the research. According to STAT, “The research team did not clear the work” with the NIAID, leading the agency to look “for some answers as to why it first learned of the work through media reports.”

Dr. Emily Erbelding, M.P.H., director of the NIAID’s Division of Microbiology and Infectious Diseases, told STAT that the research team’s “original grant applications did not specify that the scientists wanted to do this precise work. Nor did the group make clear that it was doing experiments that might involve enhancing a pathogen of pandemic potential in the progress reports it provided to NIAID.”

Erbelding said the NIAID is “going to have conversations” with the research team in the coming days, adding that “we wish that they would have” informed NIAID of the “intent of the research.”

According to Erbelding, this would have likely resulted in a committee being convened “that would assess the risks and benefits” of the research involving “enhanced pathogens of pandemic potential.”

What the NEIDL researchers did

According to STAT, the NEIDL researchers set out “to determine if the mutations in the Omicron spike protein were responsible for this variant’s increased ability to evade the immunity to SARS-2 that humans have built up, and whether the changes led to Omicron’s lower rate of severity.”

The research involved extracting the Omicron variant’s spike protein and attaching it to the original strain.

Put differently, the scientists took the deadliest COVID-19 strain and combined it with the spike protein from the most infectious strain. They then infected laboratory mice and human cells with the new hybrid strain.

The results showed that while the Omicron variant’s spike protein was responsible for the variant’s ability to evade immunity developed via infection, vaccination or both, it is not responsible for the decrease in the severity of the Omicron strain.

According to the Daily Mail :

“The researchers looked at how mice fared against the new hybrid strain compared to the original Omicron variant.

“When a similar group of rodents were exposed to the standard Omicron strain, however, they all survived and only experienced ‘mild’ symptoms. …

“[The researchers] found the hybrid strain produced five times more viral particles than the original Omicron.”

According to the MetroUK, “The scientists also infected human cells with the hybrid variant and found it was five times more infectious than Omicron.”

In the preprint, the researchers wrote:

“We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant.

“The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor-binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells.

“In K18-hACE2 mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%. This indicates that while the vaccine escape of Omicron is defined by mutations in S, major determinants of viral pathogenicity reside outside of S.”

In a statement remarking on the outcome of the study, NEIDL’s Saeed, who is also an assistant professor of biochemistry at Boston University, said:

“Consistent with studies published by others, this work shows that it is not the spike protein that drives Omicron pathogenicity, but instead other viral proteins.

“Determination of those proteins will lead to better diagnostics and disease management strategies.”

Media focuses on study’s findings, but critics more concerned about the research itself

Some media outlets focused on the researchers’ findings that 100% of the mice infected with the engineered virus died.

Others, however, downplayed the study’s findings. According to Fox News, for example, one of the study’s limitations was that the specific breed of mice used may not provide an accurate model for the risk posed to humans, “as other types [of mice] are more similar to humans.”

In a blog post, commentator Alex Berenson, a former writer for The New York Times, also addressed the sensationalism surrounding the study’s findings, pointing out that while an 80% fatality rate in lab mice sounds bad, 100% of the mice that previously were infected with the wild variety of COVID-19 had died.

He wrote:

“[The research] says the Omicron/wild-type Sars-Cov-2 combination the researchers created is more lethal than Omicron.

“However, it ALSO says the Omicron/wild type virus is LESS lethal than [the] original wild type. Neither of those findings should be a surprise. Omicron is much less dangerous than the original Sars-Cov-2, so blending the two together produces a virus with intermediate lethality.

“What’s with the 80 percent mortality rate then? It’s in mice, people. And guess what? The wild-type had a 100 percent mortality rate in mice. Yes, all the mice infected with the original Sars-Cov-2 died. I think we can agree that Sars-Cov-2 does not have a 100 percent mortality rate in humans.”

Specifically addressing the probable risk to humans, Berenson added:

“Nor did the researchers provide any evidence that the blended Omicron/wild-type coronavirus is able to defeat antibodies in people who have been infected with and recovered from Omicron. Which is basically all of us. (They did show that both the original Omicron and their variant beats the mRNA vaccines, but that fact is not a surprise either.)”

Erbelding shared similar remarks, stating, “That 80% kill rate, that headline doesn’t tell the whole story, because Wuhan” — the original strain — “killed all the mice.”

In turn, behind its headline, the Daily Mail wrote, “The scientists admit the hybrid virus is unlikely to be as deadly in humans as it was in mice,” adding, “This is because the specific breed of lab mice used are very susceptible to severe COVID disease. Mice and humans also have very different immune responses to the virus.”

STAT also remarked on this point, writing:

“The fatality rate seen in this strain of mice when they were infected with these viruses raises questions about how good a model they are for what happens when people are infected with SARS-2. The Wuhan strain killed less than 1% of people who were infected.”

But Boyle and Rose and others, like David Livermore, Ph.D., a professor of microbiology at the University of East Anglia, and Shmuel Shapira, an Israeli government scientist, said the news coming out of NEIDL was less about the study’s results and more about the research itself.

Livermore told the Daily Mail, “Given the strong likelihood that the COVID pandemic originated from the escape of a lab-manipulated coronavirus in Wuhan, these experiments seem profoundly unwise.”

Shapira also condemned the research. “This should be totally forbidden, it’s playing with fire,” he said.

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Michael Nevradakis, Ph.D., based in Athens, Greece, is a senior reporter for The Defender and part of the rotation of hosts for CHD.TV’s “Good Morning CHD.”

This article was originally published by The Defender — Children’s Health Defense’s News & Views Website under Creative Commons license CC BY-NC-ND 4.0. Please consider subscribing to The Defender or donating to Children’s Health Defense.

October 19, 2022 - Posted by aletho | Science and Pseudo-Science, Timeless or most popular, War Crimes | Anthony Fauci, United States