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Time to assume that health research is fraudulent until proven otherwise?

By Richard Smith | BMJ | July 5, 2021

Health research is based on trust. Health professionals and journal editors reading the results of a clinical trial assume that the trial happened and that the results were honestly reported. But about 20% of the time, said Ben Mol, professor of obstetrics and gynaecology at Monash Health, they would be wrong. As I’ve been concerned about research fraud for 40 years, I wasn’t that surprised as many would be by this figure, but it led me to think that the time may have come to stop assuming that research actually happened and is honestly reported, and assume that the research is fraudulent until there is some evidence to support it having happened and been honestly reported. The Cochrane Collaboration, which purveys “trusted information,” has now taken a step in that direction.

As he described in a webinar last week, Ian Roberts, professor of epidemiology at the London School of Hygiene & Tropical Medicine, began to have doubts about the honest reporting of trials after a colleague asked if he knew that his systematic review showing the mannitol halved death from head injury was based on trials that had never happened. He didn’t, but he set about investigating the trials and confirmed that they hadn’t ever happened. They all had a lead author who purported to come from an institution that didn’t exist and who killed himself a few years later. The trials were all published in prestigious neurosurgery journals and had multiple co-authors. None of the co-authors had contributed patients to the trials, and some didn’t know that they were co-authors until after the trials were published. When Roberts contacted one of the journals the editor responded that “I wouldn’t trust the data.” Why, Roberts wondered, did he publish the trial? None of the trials have been retracted.

Later Roberts, who headed one of the Cochrane groups, did a systematic review of colloids versus crystalloids only to discover again that many of the trials that were included in the review could not be trusted. He is now sceptical about all systematic reviews, particularly those that are mostly reviews of multiple small trials. He compared the original idea of systematic reviews as searching for diamonds, knowledge that was available if brought together in systematic reviews; now he thinks of systematic reviewing as searching through rubbish. He proposed that small, single centre trials should be discarded, not combined in systematic reviews.

Mol, like Roberts, has conducted systematic reviews only to realise that most of the trials included either were zombie trials that were fatally flawed or were untrustworthy. What, he asked, is the scale of the problem? Although retractions are increasing, only about 0.04% of biomedical studies have been retracted, suggesting the problem is small. But the anaesthetist John Carlisle analysed 526 trials submitted to Anaesthesia and found that 73 (14%) had false data, and 43 (8%) he categorised as zombie. When he was able to examine individual patient data in 153 studies, 67 (44%) had untrustworthy data and 40 (26%) were zombie trials. Many of the trials came from the same countries (Egypt, China, India, Iran, Japan, South Korea, and Turkey), and when John Ioannidis, a professor at Stanford University, examined individual patient data from trials submitted from those countries to Anaesthesia during a year he found that many were false: 100% (7/7) in Egypt; 75% (3/ 4) in Iran; 54% (7/13) in India; 46% (22/48) in China; 40% (2/5) in Turkey; 25% (5/20) in South Korea; and 18% (2/11) in Japan. Most of the trials were zombies. Ioannidis concluded that there are hundreds of thousands of zombie trials published from those countries alone.

Others have found similar results, and Mol’s best guess is that about 20% of trials are false. Very few of these papers are retracted.

We have long known that peer review is ineffective at detecting fraud, especially if the reviewers start, as most have until now, by assuming that the research is honestly reported. I remember being part of a panel in the 1990s investigating one of Britain’s most outrageous cases of fraud, when the statistical reviewer of the study told us that he had found multiple problems with the study and only hoped that it was better done than it was reported. We asked if he had ever considered that the study might be fraudulent, and he told us that he hadn’t.

We have now reached a point where those doing systematic reviews must start by assuming that a study is fraudulent until they can have some evidence to the contrary. Some supporting evidence comes from the trial having been registered and having ethics committee approval. Andrew Grey, an associate professor of medicine at the University of Auckland, and others have developed a checklist with around 40 items that can be used as a screening tool for fraud (you can view the checklist here). The REAPPRAISED checklist (Research governance, Ethics, Authorship, Plagiarism, Research conduct, Analyses and methods, Image manipulation, Statistics, Errors, Data manipulation and reporting) covers issues like “ethical oversight and funding, research productivity and investigator workload, validity of randomisation, plausibility of results and duplicate data reporting.” The checklist has been used to detect studies that have subsequently been retracted but hasn’t been through the full evaluation that you would expect for a clinical screening tool. (But I must congratulate the authors on a clever acronym: some say that dreaming up the acronym for a study is the most difficult part of the whole process.)

Roberts and others wrote about the problem of the many untrustworthy and zombie trials in The BMJ six years ago with the provocative title: “The knowledge system underpinning healthcare is not fit for purpose and must change.” They wanted the Cochrane Collaboration and anybody conducting systematic reviews to take very seriously the problem of fraud. It was perhaps coincidence, but a few weeks before the webinar the Cochrane Collaboration produced guidelines on reviewing studies where there has been a retraction, an expression of concern, or the reviewers are worried about the trustworthiness of the data.

Retractions are the easiest to deal with, but they are, as Mol said, only a tiny fraction of untrustworthy or zombie studies. An editorial in the Cochrane Library accompanying the new guidelines recognises that there is no agreement on what constitutes an untrustworthy study, screening tools are not reliable, and “Misclassification could also lead to reputational damage to authors, legal consequences, and ethical issues associated with participants having taken part in research, only for it to be discounted.” The Collaboration is being cautious but does stand to lose credibility—and income—if the world ceases to trust Cochrane Reviews because they are thought to be based on untrustworthy trials.

Research fraud is often viewed as a problem of “bad apples,” but Barbara K Redman, who spoke at the webinar insists that it is not a problem of bad apples but bad barrels if not, she said, of rotten forests or orchards. In her book Research Misconduct Policy in Biomedicine: Beyond the Bad-Apple Approach she argues that research misconduct is a systems problem—the system provides incentives to publish fraudulent research and does not have adequate regulatory processes. Researchers progress by publishing research, and because the publication system is built on trust and peer review is not designed to detect fraud it is easy to publish fraudulent research. The business model of journals and publishers depends on publishing, preferably lots of studies as cheaply as possible. They have little incentive to check for fraud and a positive disincentive to experience reputational damage—and possibly legal risk—from retracting studies. Funders, universities, and other research institutions similarly have incentives to fund and publish studies and disincentives to make a fuss about fraudulent research they may have funded or had undertaken in their institution—perhaps by one of their star researchers. Regulators often lack the legal standing and the resources to respond to what is clearly extensive fraud, recognising that proving a study to be fraudulent (as opposed to suspecting it of being fraudulent) is a skilled, complex, and time consuming process. Another problem is that research is increasingly international with participants from many institutions in many countries: who then takes on the unenviable task of investigating fraud? Science really needs global governance.

Everybody gains from the publication game, concluded Roberts, apart from the patients who suffer from being given treatments based on fraudulent data.

Stephen Lock, my predecessor as editor of The BMJ, became worried about research fraud in the 1980s, but people thought his concerns eccentric. Research authorities insisted that fraud was rare, didn’t matter because science was self-correcting, and that no patients had suffered because of scientific fraud. All those reasons for not taking research fraud seriously have proved to be false, and, 40 years on from Lock’s concerns, we are realising that the problem is huge, the system encourages fraud, and we have no adequate way to respond. It may be time to move from assuming that research has been honestly conducted and reported to assuming it to be untrustworthy until there is some evidence to the contrary.

Richard Smith was the editor of The BMJ until 2004.

Competing interest: RS was a cofounder of the Committee on Medical Ethics (COPE), for many years the chair of the Cochrane Library Oversight Committee, and a member of the board of the UK Research Integrity Office.

July 20, 2021 Posted by | Corruption, Deception, Science and Pseudo-Science, Timeless or most popular | Leave a comment

Should COVID-19 be a vaccine disease or a childhood disease?

By Christine S Benn & Professor Peter Aaby | BMJ | July 18, 2021

Dear Editor

In the discussion regarding COVID-19 vaccination of children, several aspects seem to be missing.

First, vaccination of children is based on a small Pfizer-sponsored phase 3 trial of 2260 adolescents randomized to BNT162b2 COVID-19 vaccine or saline. The resulting paper concludes that the vaccine ”had a favorable safety profile”(1). However, based on data presented in supplementary table 2, in the age group 12-15 years, 7/1131 vaccinated vs. 2/1129 unvaccinated had a severe adverse event (1), i.e. a 3-fold increased risk. In the 16-25 years age group presented in the same paper, 9/536 vaccinated vs. 3/561 unvaccinated had a severe adverse event (1), i.e. likewise a 3-fold increased risk. The combined results indicate a 3.28 (95% confidence interval 1.21 to 8.94)-fold increased risk in severe adverse events in the vaccinated adolescents/young adults (2). In absolute numbers, 1 of 100 vaccinated experienced a severe event, vs. 3 of 1000 unvaccinated. Data was not presented by sex.

A protective vaccine can have negative non-specific and sex-differential effects on overall health (3). For instance, a protective measles vaccine had to be withdrawn after being associated with 2-fold higher all-cause mortality for females (4). A partially protective malaria vaccine was recently likewise associated with 2-fold higher female mortality (5). These epidemiological observations indicate that while the vaccines protected against the target disease, they increased the susceptibility to other diseases. In other words, the specific protection came at the price of increased susceptibility to other diseases. This epidemiological phenomenon of negative non-specific effects has been linked to innate immune tolerance (3, 6). Though the number of participants was small, the only study so far of BNT162b2 COVID-19 vaccine indicates that this vaccine induces innate immune tolerance towards bacterial and viral ligands (7). Thus, protection against COVID-19 could come at the price of increased risk of other infections.

Other pandemic vaccines have later been found out to have caused rare but severe side effects, like Guillain-Barré syndrome in recipients of flu vaccines in 1976, and narcolepsy linked to one brand of swine flu influenza vaccine in 2009(8). None of the phase 3 trials of COVID-19 vaccines were designed to study either non-specific sex-differential effects, or rare but severe long-term side effects (8).

Given the low risk of severe COVID-19 in previously healthy children – none in the Pfizer-sponsored phase 3 trial (1) – it is not clear that vaccine benefits outweigh harm in healthy children.

Second, arguments for vaccinating children include that infection in children could lead to more dangerous variants. Variants of concern have typically been the result of persistent infections in immunocompromised people that can cause the virus to mutate more frequently because the person’s immune system cannot clear the virus as quickly as the immune system of a healthy person (9). Presumably healthy children, who typically have very mild/short-lasting infections, are unlikely to give rise to variants of concern. Noteworthy, individuals, who have had COVID-19 infection, will likely have broad resistance towards SARS-CoV2 variants(10), and thus contribute importantly to herd immunity.

This leads us to the third point: Should COVID-19 be a vaccine disease or a childhood disease? There has been surprisingly little discussion about the future of COVID-19. Many people seem to assume that COVID-19 will become a disease for which we vaccinate the whole population perhaps annually or biannually. This will be expensive – and potentially harmful, if the (repeated) vaccinations have negative effects. We do not think vaccination of the whole population is necessary either; in fact, it may be counter-productive for society.

The known endemic human Corona-viruses (HCoV) infect most people before age 15; thereafter people may become re-infected again, but as evidenced by the lack of IgM responses, the response is a recall response (11). These HCoV rarely cause severe disease until the age of immunosenescence and we would never contemplate vaccinating against HCoVs at the population level, even if vaccines existed.

Given that we are so lucky that SARS-CoV2 very rarely cause severe disease in children, the safest and cheapest way forward seems to be to tame SARS-CoV2 to a common childhood disease like other HCoV. This would happen by allowing SARS-CoV2 to infect children, who thereby likely become protected against severe disease well into late adulthood. Importantly, this transition of SARS-CoV2 into a childhood disease would be delayed if there is too little SARS-CoV2 circulating. As noted by others: “Once most adults are vaccinated, circulation of SARS-CoV-2 may in fact be desirable, as it is likely to lead to primary infection early in life when disease is mild, followed by booster re-exposures throughout adulthood … This would keep reinfections mild and immunity up to date”(12).

In conclusion, there are good arguments why not vaccinating children may in fact serve several purposes at the individual as well as at the societal level:
• Not vaccinating children protects children against the potential unknown harms of COVID-19 vaccinations.
• Not vaccinating children gives them the opportunity to develop a broad natural immunity, contributing to herd immunity, and speeding up the transition of SARS-CoV2 into a childhood disease.
The avoided costs of making COVID-19 a vaccine disease, for which we vaccinate the whole population maybe annually or biannually, could be well spent on other health related issues such as smoking, cancer, obesity, and mental health.

References:

1. Frenck RW, Jr., Klein NP, Kitchin N, Gurtman A, Absalon J, Lockhart S, et al. Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents. N Engl J Med. 2021.
2. Benn CS. https://www.linkedin.com/posts/christine-stabell-benn_safety-immunogenic…. LinkedIn post 2021.
3. Benn CS, Fisker AB, Rieckmann A, Sørup S, Aaby P. Vaccinology: time to change the paradigm? Lancet Infect Dis. 2020.
4. Aaby P, Jensen H, Samb B, Cisse B, Sodemann M, Jakobsen M, et al. Differences in female-male mortality after high-titre measles vaccine and association with subsequent vaccination with diphtheria-tetanus-pertussis and inactivated poliovirus: reanalysis of West African studies. Lancet. 2003;361(9376):2183-8.
5. Klein SL, Shann F, Moss WJ, Benn CS, Aaby P. RTS,S Malaria Vaccine and Increased Mortality in Girls. MBio. 2016;7(2):e00514-16.
6. Blok BA, de Bree LCJ, Diavatopoulos DA, Langereis JD, Joosten LAB, Aaby P, et al. Interacting, Nonspecific, Immunological Effects of Bacille Calmette-Guerin and Tetanus-diphtheria-pertussis Inactivated Polio Vaccinations: An Explorative, Randomized Trial. Clin Infect Dis. 2020;70(3):455-63.
7. Föhse FK, Geckin B, Overheul GJ, van de Maat J, Kilic G, Bulut O, et al. The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses. medRxiv. 2021:2021.05.03.21256520.
8. Doshi P. Will covid-19 vaccines save lives? Current trials aren’t designed to tell us. Bmj. 2020;371:m4037.
9. Peacock TP, Penrice-Randal R, Hiscox JA, Barclay WS. SARS-CoV-2 one year on: evidence for ongoing viral adaptation. J Gen Virol. 2021;102(4).
10. Ferretti AP, Kula T, Wang Y, Nguyen DMV, Weinheimer A, Dunlap GS, et al. Unbiased Screens Show CD8(+) T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein. Immunity. 2020;53(5):1095-107.e3.
11. Zhou W, Wang W, Wang H, Lu R, Tan W. First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood. BMC Infect Dis. 2013;13:433.
12. Lavine JS, Bjornstad O, Antia R. Vaccinating children against SARS-CoV-2. BMJ. 2021;373:n1197.

Competing interests: No competing interests

Christine S Benn & Professor Peter Aaby
Bandim Health Project, Department of Clinical Research, University of Southern Denmark
Studiestræde 6, 1455 Copenhagen K, Denmark
@StabellBenn

July 20, 2021 Posted by | Science and Pseudo-Science, Timeless or most popular | | Leave a comment

Why the EU’s Carbon Border Tax will Fail to Stop Carbon Leakage

By Eric Worrall | Watts Up With That? | July 20, 2021

The EU is once again attempting to impose a carbon tax on all imports, to stop “carbon leakage”, the loss of manufacturing or other businesses relocating to lower cost countries. But a few simple economic calculations demonstrate why the EU’s plan will not stop the ongoing haemorrhage of business activity.

Carbon Border Adjustment Mechanism: Questions and Answers

Why is the Commission proposing a Carbon Border Adjustment Mechanism?

The EU is at the forefront of international efforts to fight climate change. The European Green Deal sets out a clear path towards realising the EU’s ambitious target of a 55% reduction in carbon emissions compared to 1990 levels by 2030, and to become a climate-neutral continent by 2050.

The July 2021 package in support of the EU’s climate targets is an integral part of our strategy to achieve this, and will further seal the EU’s reputation as a global climate leader. As part of these efforts, the Carbon Border Adjustment Mechanism (CBAM) is a climate measure that should prevent the risk of carbon leakage and support the EU’s increased ambition on climate mitigation, while ensuring WTO compatibility.

Climate change is a global problem that needs global solutions. As we raise our own climate ambition and less stringent environmental and climate policies prevail in non-EU countries, there is a strong risk of so-called ‘carbon leakage’ – i.e. companies based in the EU could move carbon-intensive production abroad to take advantage of lax standards, or EU products could be replaced by more carbon-intensive imports. Such carbon leakage can shift emissions outside of Europe and therefore seriously undermine EU and global climate efforts. The CBAM will equalise the price of carbon between domestic products and imports and ensure that the EU’s climate objectives are not undermined by production relocating to countries with less ambitious policies.

…

Read more: https://ec.europa.eu/commission/presscorner/detail/en/qanda_21_3661

Why does this tax put an EU producer at a disadvantage?

EU Border Tax – No Sale

Simple – selling to another EU entity is price competitive, so far, but selling outside the EU is impossibly expensive, because you are competing with other sellers who don’t pay EU carbon taxes. An exporter outside the EU has an advantage over a manufacturer inside the EU, even if they have to pay a carbon border adjustment.

What about if the EU tries to level the playing field for EU based exporters, and applies a tax credit to exports? This opens the door to massive global carbon carousel fraud.

EU Carbon Tax Carousel Fraud

EU Carbon Tax Carousel Fraud

Either the EU destroys their own exporters, in an attempt to protect their domestic industry, or they have a big firefight on their hands, trying to contain carbon carousel fraud, which will only get worse any time they try to ratchet up their carbon price.

What about the effect of carbon pricing on businesses inside the EU carbon tax zone?

Classic supply and demand graph

Classic supply and demand graph, showing the impact on quantity of a tax driven rise in price per unit.

In this case quantity is assumed to be a proxy for economic activity.

Ever visited a shopping centre, and wondered why all the interesting shops are slowly replaced by clothes shops or other high turnover businesses? The reason is all those interesting shops are not profitable enough to pay the rent, and over time they are replaced by simpler, less interesting businesses – safe, boring, profitable, but still a contraction in the diversity of life choices available to consumers.

Pretty much the same thing would happen to domestic high carbon businesses afflicted by EU carbon pricing.

The EU at least in principle likely hopes that revenue from the carbon tax will drop to zero, as people discover low carbon or zero carbon alternatives to the high carbon goods they currently use such as alumina, or simply learn to live without.

But this is a huge gamble. The only reason for carbon leakage in the first place is because the carbon intensive goods targeted by the EU are difficult to replace with low carbon alternatives, and difficult to live without.

If a carbon intensive good is irreplaceable, continued dependency on that high carbon good will be an ongoing anchor dragging on the European economy.

Of course you could make an argument that the benefits the people of the EU receive from reduced CO2 emissions outweigh the costs, that one day our descendants will thank us for giving them the opportunity to experience cold weather. But this does not help consumers and businesses today.

In conclusion, the EU carbon border adjustment will do nothing to prevent carbon leakage. The EU does not control enough of the global economy to make it more than an inconvenience for multinationals. The only people the EU border carbon adjustment will hurt are people living in the EU, who will see their choices and opportunities contract.

July 20, 2021 Posted by | Economics, Science and Pseudo-Science, Timeless or most popular | | Leave a comment

‘Climate Change’ Charlatanism Means Never Having to Say You’re Sorry

By John O’Sullivan • The Pipeline • July 18, 2021

Professor Ole Humlum is a former Professor of Physical Geography at the University Centre in Svalbard, Norway, and Emeritus Professor of Physical Geography, University of Oslo, Norway. He specializes in reporting and analyzing annual changes in the climate. I wrote about the professor’s work just over a year ago on this site. His report, published annually by the Global Warming Policy Foundation in London, was moderately optimistic on climate changes in 2019, pointing out that some of them were for the better, some worse, but that overall there was no justification for the alarmist rhetoric of climate emergency. For instance, as I then wrote,

He points out  that new data on rising ocean temperatures raise interesting questions about the source of the heat. We can detect a great deal of heat rising from the bottom of the oceans. This obviously cannot be anything to do with human activity.

Since annual reports come out every year, his latest report on the world’s climate in 2020 has just been published. It covers the waterfront from Atlantic Multidecadal Oscillation to Zonal Air Temperatures, and though most of it is addressed to technical specialists, it reaches some broad general conclusions that can be grasped by the layman. By and large these are a mix of moderate changes, long-term stability in main trends, and some trends getting worse but falling short of a climate emergency. Here, for instance, is his summing-up of changes in snow cover:

Variations in global snow-cover extent are driven by changes in the Northern Hemisphere, where most of the major land masses are located. Southern Hemisphere snow-cover extent is essentially controlled by the Antarctic ice sheet, and is therefore relatively stable. Northern Hemisphere average snow cover has also been stable since the advent of satellite observations, although local and regional inter-annual variations may be large. Considering seasonal changes in the Northern Hemisphere since 1979, autumn extent has been slightly increasing, mid-winter extent has been largely stable, and spring extent has been slightly decreasing. In 2020, Northern Hemisphere seasonal snow cover was somewhat below that of the preceding years.

And here is his account of storms and hurricanes in 2020:

The most recent data on numbers of global tropical storms and hurricane accumulated cyclone energy (ACE) are well within the range seen since 1970. In fact, the ACE data series displays a variable pattern over time, with a significant 3.6-year variation, but without any clear trend towards higher or lower values. A longer ACE series for the Atlantic Basin (since 1850), however, suggests a natural cycle of about 60 years’ duration for tropical-storm and hurricane ACE. The number of hurricane landfalls in the continental United States remains within the normal range for the entire record since 1851. (My italics.)

Not easy reading, as you can see, but worthwhile because it records what actually happened to the climate in the last year. And that picture contrasts strongly with two things: the general impression of what happened to the climate given by the mainstream media, and the forecasts drawn from computer modelling in previous years of what would happen to the climate. Those two things generally reinforce each other almost as if the media reports those real climate events that reflect the media “narrative” and ignore or gloss over those that don’t. The truth rarely, if ever, catches up with the predictions in mainstream news reporting.

Time and again the dates for which catastrophe was confidently predicted have passed without grave occurrences, as I wrote a year ago. No apologies are offered, and no signs given that the forecasters will be reconsidering the theories on which their forecasts either were based or by which they will in future be supported.

To be sure, that’s a problem not confined to climate science. There’s a general crisis of “replication” or “reproducibility” in science as scientists themselves have been debating in the last decade. As Wikipedia sums it up:

A 2016 poll of 1,500 scientists conducted by Nature reported that 70 percent of them had failed to reproduce at least one other scientist’s experiment (including 87 percent of chemists, 77 percent of biologists, 69 percent of physicists and engineers, 67 percent of medical researchers, 64 percent of earth and environmental scientists, and 62 percent of all others), while 50 percent had failed to reproduce one of their own experiments, and less than 20 percent had ever been contacted by another researcher unable to reproduce their work. Only a minority had ever attempted to publish a replication, and while 24 percent had been able to publish a successful replication, only 13 percent had published a failed replication, and several respondents that had published failed replications noted that editors and reviewers demanded that they play down comparisons with the original studies.

That’s bad enough. Worse, common sense suggests that the rate of failed replications will be higher in forecasting than in already performed physical experiments. To replication failure and prediction failure, however, we should probably add a third crisis—namely, impartiality failure on the part of the mainstream media—if we are to understand how bad things are.

The latest example of this is the media treatment of a new book, Unsettled: What Climate Science Tells Us, What It Doesn’t, and Why It Matters, by Steven Koonin, a physicist specializing in energy policy who served as an Under-Secretary for Energy for Science in the Obama administration. He doubts some of the claims allegedly accepted as valid by a “consensus” of scientists. Koonin has since come under fierce attack from those scientific reviewers who in turn doubt his own claims. That’s well and good—it’s how science is supposed to operate until experiments settle the argument conclusively–for the moment. In the meantime Koonin must fight his corner as best he can—as apparently he intends to do.

What is objectionable is that social media should tilt an already tilted playing field so that its “fact-checkers” preface information about “Unsettled” with a kind of health warning that its statistics are unreliable and that the book itself “denialist” when in fact Koonin denies not climate warming but some arguments about its speed, extent, and whether we’re pursuing the right mix of mitigation and adaptation in dealing with it. That’s a debate we need—and which we’re bound to have anyway because of the looming costs of Net-Zero.

Suppressing debate simply won’t work. And that’s likely to be demonstrated soon. Koonin has agreed to give the GWPF’s annual lecture in November in London. My guess is that the Foundation will have to hire a larger-than-usual hall to accommodate an audience drawn there by today’s equivalent of “Banned in Boston”—namely, “Not Available on Social Media.”

July 20, 2021 Posted by | Science and Pseudo-Science, Timeless or most popular | | Leave a comment

Covid vaccines: We’ve been misled from the very start

By Neville Hodgkinson | The Conservative Woman | July 20, 2021

IT IS truly amazing how self-deceiving a profession that sets out to help and heal sick people can be when it comes to acknowledging that the cure is sometimes worse than the illness. Evidence is mounting that just such a state of denial is manifesting in the mass rollout of the Covid vaccine.

Decades ago, I examined evidence for the effectiveness of flu vaccine and found that it rested entirely within studies showing an increase in antibodies to the circulating virus, but that this did not translate into less illness.

A group of GPs who were uneasy about the impact of the vaccine on old and frail people set up a trial of their own in which they found that those who had the jab had no less flu, but more non-specific illness, in the ensuing year compared with a group of similar frailty who were not inoculated.

Similarly, doctors at two boarding schools who conducted trials among their own pupils dropped the vaccine after finding it was of no benefit.

It would be almost impossible to do similar studies today because the NHS mounts such a relentless campaign every winter to have everyone vaccinated. It is in effect the marketing arm for the flu vaccine manufacturers, of which GlaxoSmithKline, Sanofi and AstraZeneca are leading players, making billions from the jabs.

The UK-based Cochrane research network, however, has been constantly evaluating global studies on the effectiveness of flu vaccinations since 1999. Put together, the data from dozens of well-conducted studies covering more than 80,000 participants fails to prove a reduction in deaths from flu or flu-like illnesses, and shows that vaccinations could even increase the number of hospitalisations.

Germany’s renowned Robert Koch Institute has found clear evidence that for the over-60s, in the 2017/18 and 2018/19 flu seasons, vaccination increased the risk of flu instead of protecting against it.

The fact that despite the scientific evidence, illusions still continue about such a commonly used vaccine bodes ill for hopes that governments and their advisers will listen to the evidence with regard to Covid-19.

The mantra that the jab is ‘safe and effective’ is becoming a sick joke.  There is now massive evidence of harm and mounting evidence that it does not work anything like as well as hoped.

The harm is there for all to see. As of mid-June, UK regulators received 276,867 adverse events reports, including 1,332 deaths; in the US, there were more than 6,000 deaths, and 400,000 events serious enough to be reported; and in the European Union, some 1,500,000 injuries and 15,000 deaths.

Claims that these reports are unconfirmed as cause-and-effect related are countered by the argument ‘Where is the proof that they are not?’ Under-reporting is known to be common, and many of the injuries occurred within hours or days of the victim receiving the jab.   There has never been a vaccine with anything like this measure of recorded harm.

Government agencies assert that thousands of lives have been saved by the vaccination drives. But wherever the claims are examined carefully, as opposed to being passed on by doctors and journalists who accepted them uncritically and are now desperately hoping they are true, the evidence is found to be increasingly thin.

As Dr Will Jones noted in the newly launched Daily Sceptic (formerly Lockdown Sceptics), latest data from the ZOE app, the world’s largest ongoing study of Covid-19, shows that as of July 12, infections in the vaccinated (at least one dose) in the UK now outnumber those in the unvaccinated for the first time, as the former continue to surge while the latter plummet.

What does Germany’s Robert Koch Institute, which seems more independent-minded than leaders of the UK’s state-run NHS, tell us about the Covid vaccine?

It published a 74-page paper last January in which the effectiveness in the age group 75 and over was said to be ‘subject to a high degree of uncertainty’ and no longer statistically significant. What’s more, the quality of the data across all age groups, based on proof of prevention of serious illness, was ‘very low’.

Reporting these findings, the German magazine Multipolar said it was scandalous that they are not mentioned in their government’s information services, and that the big media remain silent on the topic.

In truth, we have been misled about the vaccine from the start.  Repeatedly publicised claims of 95 per cent ‘efficacy’ do not mean you are 95 per cent protected against Covid if you have the jab.

They are based on studies such as Pfizer’s in which 40,000 participants in different countries were divided into two groups, one of which received the vaccine and the other a placebo. There were no deaths in either group, so the trial told us nothing about risk of death. But 162 of the placebo group were designated Covid cases, compared with only eight among those vaccinated. The diagnosis was on the basis of the participants having one or more symptoms of the disease, confirmed through a lab test.

Eight compared with 162 gives what is called a relative risk reduction (RRR) of 95 per cent. It is a self-contained figure that has only a marginal bearing on the experience of the trial participants generally.

What we rarely hear about is what is known as the absolute risk, that is, the percentage of cases reported in each group of 20,000. For the vaccinated individuals, their chances of becoming a case were 0.04 per cent, and for the placebo group, 0.75 per cent. That represents an absolute risk reduction (ARR) of 0.71 per cent (0.75 per cent minus 0.04 per cent) which does not sound like much to write home about. Even that was probably an exaggeration, because side-effects in the vaccinated group would have been obvious to observers, making them less likely to report them as cases.

It gets even worse. One of the criteria of a ‘case’ in the trials was that it should be contracted not earlier than seven days after the second jab. That helped keep the number down enormously – to only eight – in the vaccinated group. This is because so many vaccine recipients have Covid-like symptoms in the first few days after the jab.

A subsequent analysis, hidden away in a report by the US Food and Drug Administration, found that when Covid-like symptoms reported in those first few days were included, there were 407 cases among the vaccinated compared with only 287 in the placebo group, an entirely different risk-benefit picture and one consistent with many studies showing an increase in death rates among the elderly immediately after the jab.

All of this means we should not be surprised to find that ‘a disturbing trend’ has appeared among the most vaccinated nations in the world, as TrialSite News reports. In Gibraltar, Malta, Seychelles, UAE and the Isle of Man, Covid cases are considerably up, including deaths in some of these nations, despite ‘overwhelming’ percentages of their populations being vaccinated.

Israel, too, with 81 per cent of its adult population fully vaccinated and cases that went right down to a handful a day, is now seeing a surge in new infections, of which an estimated 40-50 per cent are in vaccinated individuals.

Is this because of a new variant of the virus, against which the existing vaccines don’t work? Will it mean subjecting ourselves to booster shots, with the accompanying risks, every few months? Or is it because there is ultimately going to be no escaping actual infection with the virus?

We just do not know.

There is one light in the darkness. Several studies have shown that once an individual has had the infection, even if only mildly, their immune system develops lasting protection against the toxic spike protein encoded by the genetically engineered virus.

July 20, 2021 Posted by | Deception, Science and Pseudo-Science | | Leave a comment

The BBC vs Donald Trump

By Freddie Attenborough | The Daily Sceptic | July 19, 2021

In March 2021, the BBC reported that one of their investigative teams had, “Been tracking the human toll of coronavirus misinformation”. During this investigation they claimed to have found links to “assaults, arsons and deaths”. Worryingly, experts also told them that, “The potential for indirect harm caused by rumours, conspiracy theories and bad health information could be much worse”. Sounds like an interesting investigation, doesn’t it? Public service output at its finest, you might think. Just the kind of article we’d all like to read.

Alas. Not quite.

The problem with the BBC is that it simply can’t help itself. Having teed an ostensibly interesting story up in this open, investigatory journalistic type of way, its authors then proceed to devote a good-ish chunk of what follows to that most favourite of all BBC pastimes, namely, implicating Donald Trump in the act of mass murder. As with the butterfly so beloved of chaos theory (you know the one: that little blighter who’s always flapping his wings and causing  tsunamis to crash into the coast of Bangladesh) no sooner have the BBC shown us Trump tweeting about the FDA’s preliminary research into hydroxychloroquine as a prophylactic against Covid than the magic of non-deterministic linear physics kicks in and people all over Nigeria and Vietnam suddenly start mopping up the old bleach-based products like vacuum cleaners.

In the end, then, the only interesting thing about this article is the way it reminds us just how little time and attention the BBC have paid to exploring the link that surely must exist between Covid ‘misinformation’ (as they themselves insist on calling it) and the huge rise in cases of psychosomatic disorder – health anxiety in particular – that we’ve witnessed in the UK since the dawn of the Age of Lockdown (2020-present). Let me explain what I mean.

And to do so, let me start by asking a question: what might disinformation likely to precipitate new, or to heighten existing, levels of anxiety amongst those suffering from psychosomatic disorders look like? How, in other words, might we define such a thing? Well, perhaps we might say that it would be information that unduly exaggerated the risks associated with Covid. Perhaps we might go further and say that it would represent the risks associated with Covid in a highly misleading and/or a sensationalist way. Come to think of it, perhaps we might end up concluding that it would look rather like the BBC’s recent article, ‘Long COVID funding to unearth new treatments.’ Below is the thumbnail picture accompanying the piece.

As you can see, it depicts two masked patients, chaperoned by two masked nurses, who look unmistakably like they’re having to learn how to walk again. (And by the way, anyone who’s going to counter that it could just as plausibly be a depiction of two patients being tested for, say, oxygen carrying capacity or pulse rate during recovery from a respiratory illness like Covid would need to explain to me why it is that neither patient is shown to be wearing any tracking/monitoring equipment, and, in addition, why neither nurse is shown to be holding/studying any data monitors). The male patient in the foreground of the image looks particularly unsteady on his feet, relying heavily on the metal frame surrounding him for bodily support. One of the masked nurses stands next to him, watching his legs and feet intently, presumably scanning for any warning signs of imminent collapse or a stumble. Her right arm is stretching out towards him, and no doubt a guiding/supportive hand is resting on the patient’s shoulder. Just behind the male patient, you can also see the lower half of the wheelchair in which he will have been brought from his hospital ward and into this rehabilitation class.

But if that’s what it shows, then what kind of patient might actually need rehabilitation of this kind; rehabilitation, that is, in which patients are having to learn how to walk again? It’s the type of thing that you’d imagine is normally reserved for patients needing post-surgery rehabilitation; patients who’ve suffered spinal cord injuries, neurological disorders, car-crashes, amputations and the like. That’s big league, serious stuff. We’re essentially talking about a type of rehabilitative treatment for people who’re on the cusp of, or who’re already suffering from, life-changing injuries/illnesses.

So is this the type of treatment that people suffering from Long Covid are likely to need? I ask because as we’ve already established, it’s the type of treatment that’s depicted in the image the BBC have attached to an article entitled, “Long Covid funding to unearth new treatments” the first paragraph of which reads: “Thousands of people with ‘long Covid’ could benefit from the funding of 15 new studies of the condition, its causes and potential treatments”. To help us on the way towards answering this question, here’s what the NHS guide to the symptoms currently associated with ‘Long Covid’ has to say for itself:

Common Long Covid symptoms include:

  • extreme tiredness (fatigue)
  • shortness of breath
  • chest pain or tightness
  • problems with memory and concentration (‘brain fog’)
  • difficulty sleeping (insomnia)
  • heart palpitations
  • dizziness
  • pins and needles
  • joint pain
  • depression and anxiety
  • tinnitus, earaches
  • feeling sick, diarrhoea, stomach aches, loss of appetite
  • a high temperature, cough, headaches, sore throat, changes to sense of smell or taste
  • rashes

Now I’m no doctor, admittedly, but I’m not entirely satisfied that a programme of rehabilitative walking usually reserved for wheelchair bound patients in post-surgery recovery is going to prove particularly efficacious when it comes to the treatment of long Covid patients with earache, diarrhoea and changes of smell or taste. In fact, I’m not satisfied at all.

Indeed it rather seems to me that the BBC’s choice of image, when considered as an accompaniment to this particular article, might justifiably be described as misinformation; that is, as information that unduly exaggerates the risks associated with long Covid in a highly misleading or a sensationalist way.

By the way, do you like my definition of misinformation? Thanks. Perhaps it might interest you, then, to know it’s culled from the BBC’s own editorial guidelines. Specifically, therein we find “Section 3, Accuracy”, and, more particularly, “Sub-section 3.3.24”, which states that, “Reconstructions [which this image undeniably is] are when events are quite explicitly re-staged”, and that in order to abide by the BBC’s editorial guidelines, “They should normally be based on a substantial and verifiable body of evidence… [and they] should not overdramatise in a misleading or sensationalist way”.

On this basis, then, is it not the case that the BBC’s own reality-check team, that bastion of fairness and impartiality in a world gone wrong, should hold the organisation to account for spreading long Covid misinformation? Is it not an article that exaggerates and sensationalises the effects of long Covid? Further, is it not likely to generate additional, or indeed to heighten existing cases of, psychosomatic health disorders in the U.K.?

I guess if you’re the type of person who’s already suffering from heightened worry about your health, about lockdown, about physical contact with others, about viruses, about disease; I guess if you surf the web but never really read anything carefully; if you scan the thumbnails on the BBC’s news homepage but never click through to the articles; if you look at an article’s opening image and then only scan the first two or three paragraphs of text thereafter… then I guess, absolutely, it might indeed be considered ‘misinformation.’

“But isn’t this all just a little pedantic?” I hear you ask. “A bit nit-picky?” Oh, absolutely. And doesn’t it feel good to be playing the BBC at their own game for a change. So good, in fact, that you really must forgive me. I’m enjoying myself so much that I’m going to continue to be pedantic for a little while yet.

Because you see I guess, too, that if you’re prone to experiencing psychosomatic disorders of one kind of another, if you’re already well-known to your local GP surgery and A&E, then it might panic you quite a bit to think that the image the BBC have chosen to use here depicts a fate that might lie in store for you too if you ever contracted Covid and then experienced Long Covid. I guess too that if you’re that way inclined, then you might even feel you needed to take the vaccine, any vaccine, right this minute, no questions asked, jab jab jab, please, put it in me doctor, oh God, put it in me… and to hell with any kind of informed consent.

Jabbed or not, if you’re that way inclined then I guess you might nevertheless see that picture, that image of the Long Covid patient struggling to walk in the BBC’s article, and then, at some point later, get around to thinking that you’re experiencing the symptoms of Long Covid, that you’re really ill, that you’re dying, that you’re in need of immediate and very urgent medical attention, that you’ve got to go to A&E immediately because you might end up in a wheelchair unable to walk; I guess, too, that you might see that picture and then end up yo-yo-ing in and out of the healthcare system for the rest of your life, costing the taxpayer money, wasting valuable medical time, worrying that there’s a direct line of causality that “the science” has established between you coughing, you sneezing and you ending up in hospital needing a wheelchair to get you to your rehabilitative walking therapy sessions.

It’s strange, isn’t it? I mean, the BBC is normally so keen, so eager, to castigate others for disseminating what they’ve decreed to be Covid misinformation capable of causing or exacerbating existing physical disorders. Yet in the case of psychosomatic disorders – i.e. panic, hyperventilating, health anxiety, generalised anxiety, hypertension, depression, chills, gastrointestinal disturbances – they’re curiously reluctant to take up those same sanctimonious ‘fact-checking’ cudgels.

It’s a reluctance that matters, though, isn’t it? The sad and unfortunate thing about psychosomatic disorders is that those suffering from them are more likely than almost any other group in society to place unnecessary pressure on the NHS. After all, if you’re worried that you’re seriously unwell and/or in imminent danger of dying, where’s the first place you’re going to go? That’s right: a primary or secondary healthcare provider. The problem, of course, is that people who suffer from those types of disorders are neither seriously ill nor in imminent danger of dying. What they ‘are’ is suffering from severe anxiety. That’s not nothing, of course; but it’s hardly first responder or A&E type stuff, is it?

That this might constitute a problem during a global pandemic of a mild respiratory illness in which we’ve all been told to put our lives, businesses, careers on hold because the NHS is under massive existential pressure, seems obvious. If the NHS is already clogged up with respiratory tract illness and you then go and add a whole bunch of psychosomatic patients to the mix… well, you’ve got a problem, haven’t you? You’d think the BBC would care about that sort of thing, particularly given the pious, reverent tone it normally adopts when it’s representing the NHS. You’d think they’d want to provide balanced, calm, rational reportage of what was going on; reportage that was clear about the extremely low risk Covid poses to the vast majority of people in this country.

I wonder. Could it be that if we were to widen the scope of the concept of ‘misinformation’ to include not only information capable of causing physical harm, but also that likely to cause psychosomatic harm, we’d be forced to conclude that the BBC, with all its Covid exaggerations, its hyperbole, its uncritical, unreflexive treatment of “the science” handed down to it by SAGE, its failure to hold the Government to account, to approach statistics sceptically, to put case numbers into perspective, its obsession with filming death porn reports from inside hospitals (etc etc)… if we were to consider all of that as misinformation too, might we not end up concluding that the BBC has done as much damage to the psychological health and wellbeing of the nation it purports to inform, educate and entertain as Donald Trump ever did with his tweety-tweety chit-chat about preliminary research into hydroxychloroquine as a prophylactic against Covid? I wonder indeed.

Dr Freddie Attenborough is a former academic. You can see his substack account here.

July 19, 2021 Posted by | Fake News, Mainstream Media, Warmongering, Science and Pseudo-Science | , | Leave a comment

Britain has a choice on Freedom Day: Embrace liberty or slide into total biosecurity tyranny

By Neil Clark | RT | July 19, 2021

Domestic Covid restrictions have ended in England, but the threat to our freedoms remains, with the government urging businesses to adopt vaccine passports. The nightclub industry’s opposition to the scheme shows the way forward.

Freedom has been restored in Merrie England after 16 months of unremitting grimness the likes of which we’ve not seen since the days of Oliver Cromwell’s Commonwealth and Matthew Hopkins’ witch-hunting. Well, sort of. No more state-mandated face masks. No more state-mandated restrictions on crowd sizes at sports venues. No more ‘social distancing’. All good things in themselves – except the message from the government has been massively confused, given that it has spent the past seven days encouraging businesses to maintain restrictions. And, having ruled out vaccine passports not so long ago, the government is now very keen on them again.

Not just for the autumn and winter, but now. Check out the new Step 4 policy document released last week. It states, “The government will work with organisations that operate large, crowded settings, where people are likely to be in close proximity to others outside their household to encourage the use of the NHS COVID Pass. If sufficient measures are not taken to limit infection, the Government may consider mandating the NHS COVID Pass in certain venues at a later date.”

That’s quite a threat, isn’t it? Basically, the government is saying, “If you don’t introduce Covid certification now, we’ll do it for you.” We’ve already had a ‘Whitehall source’ informing the Daily Mail that the scheme could be used to “keep open a much wider range of venues” over the winter, when we always get an increase of people coming down ill with flu and flu-like symptoms.

The source said, “The reason we are trialling Covid certification this summer is partly to get mass events open more safely with bigger crowds, but also partly to get people used to the idea.” Nudge nudge, wink, wink, as Monty Python might have said.

Of course, another lockdown would be ruinous for the hospitality and events sector. But business now needs to call the government’s bluff. The paradox is that rejecting Covid certification won’t make another lockdown more likely, but much less so. Because at the end of the day, this is a ‘compliance test’ and has been for the past 16 months. You defeat people who threaten to close you down, not by doing what they want but by defying them – and making them back down. Otherwise you’ll only face fresh demands.

The nightclub industry shows us the way to go. Full marks to Peter Marks, the CEO of REKOM UK, which owns 42 nightclubs and who said his venues would be operating at full capacity without the need to show a negative Covid test. Marks said that would provide a ‘barrier’ to customer enjoyment. Another big player, Tokyo Industries, has also stated it won’t be going down the Covid certification route. And there’s been rejection from the pub and hospitality industry too.

Just about the only body that seems to be enthusiastically embracing the prospect of Covid passes is football’s Premier League.

It was revealed last week that the EPL was ‘working closely’ with the government and drawing up its own plans for Covid certification. What a terrible own goal that would be. A reminder: the Public Administration and Constitutional Affairs Committee report on Covid passports was absolutely damning. The cross-party group of MPs held there was “no justification” for Covid passports and that the government had failed to make the scientific case for them.

The case for Covid passports was weak enough in June, when the report came out, but is even weaker now, as almost daily we are reading of people who have had both jabs becoming ill, or even hospitalised with Covid. If the vaccine doesn’t stop transmission – which the government admits – why are vaccine passports being promoted? Answer: there is obviously another agenda. The passports are a gateway. To something very sinister indeed.

It should set everyone’s alarm bells ringing very loudly that the most prominent public promoter of the Covid certification scheme is one Anthony Linton Blair. Last September, the man who assured us Iraq had weapons of mass destruction which could be assembled and launched within 45 minutes, said it was “common sense” to move in the direction of digitalised IDs to fight coronavirus.

In June, ‘The Blair Creature’ – to use Peter Hitchens’ memorable description – declared, “The world will move to biometric ID and they will do it because in the end, it is better for people.” But which people? The vast majority of humanity, or those who meet at Davos each year and wish to control us? A ‘temporary’ Covid pass could quite easily morph into a permanent biometric ID system – which is clearly what Blair wants. And we know what that could morph into. A ‘restricted access’ social credit system, in which behaviour which is regarded as ‘good’ by the state authorities is rewarded and that which is ‘bad’ is penalised. Imagine being denied entry to a football ground or railway station, not just because you don’t have the latest Covid booster jab, but also because your ‘social credit’ score is too low after you refused to attend a ‘training course’ on ‘Good Citizenship’?

New technology means that governments have the means to control us in a way that the worst dictators in history could only dream of. It might sound a cliché, but today, on July 19, in England we really are at a crossroads. One path is marked ‘freedom’; the other takes us to a new digital servitude from which it will be very hard, if not impossible, to escape.

Neil Clark is a journalist, writer, broadcaster and blogger. His award winning blog can be found at http://www.neilclark66.blogspot.com.

July 19, 2021 Posted by | Civil Liberties, Science and Pseudo-Science | , , | Leave a comment

Do drug trials underestimate side effects?

Deadly drugs trials underestimate side effects

By Dr Sebastian Rushworth | July 19, 2021

One commonly used trick in drug trials is to exclude any group that might make the drug look worse, such as those that are more likely to experience side effects. A good recent example of this is the covid vaccine trials, which largely excluded people with auto-immune diseases (more likely to develop an auto-immune disease after vaccination), people with allergies (more likely to have an allergic reaction to the vaccine), and, of course, the elderly (less likely to develop immunity after getting the vaccine, and more likely to become seriously sick from it).

These three groups are all frequently excluded from trials, and the exclusion is particularly galling when it comes to the elderly, because they are a big segment of the population, and they are also usually the most likely to end up actually using the drugs being tested.

When drug companies have gotten a drug approved, and move on to market the drug, they will studiously avoid mentioning the fact that large segments of the population were excluded from the trials. When drug reps show their flashy powerpoints to gatherings of doctors, say for a new drug to lower blood pressure, they will always present impressive looking graphs of benefit, and they will of course point out how safe their drug was shown to be in the trials. Not once will they mention that the groups of patients the doctors will primarily be prescribing the drug to weren’t even included in the trials.

The doctors will then happily go off and prescribe the drug to multi-morbid 90 year olds, which might explain why prescription drugs are now the third leading cause of death in the western world.

The manipulation of who is included in trials is probably one of the main reasons why findings of side effects always end up being much higher in reality than in clinical trials. It might explain, for example, why muscle pain is a massively common side effect of statins in the real world, while being vanishingly rare in the statin trials (as Dr. Malcolm Kendrick has written about in detail).

A study recently published in the Lancet Healthy Longevity sought to estimate the extent to which drug trials underestimate side effects. It was funded by the UK Medical Research Council and the Wellcome Trust. The study chose as its particular focus people being treated for high blood pressure with a certain class of blood pressure lowering drugs known as RAAS blockers (which includes all drugs with names ending in -pril and all drugs with names ending in -sartan). The advantage with looking at this particular class of drugs is that there are a ton of trials. Every major pharmaceutical company has its own RAAS-blocker. It should therefore be possible to draw relatively broad conclusions about the results – whatever they show, they apply to the entire pharmaceutical industry, not just to a few specific companies. It’s also reasonable to think that the results apply to other classes of drugs too – there’s no reason to think trials of RAAS-blockers have been done differently than trials of other drug classes.

What the study sought to do more specifically was compare the rate of serious adverse events in clinical trials of RAAS-blockers with the rate observed in the real world. A serious adverse event is any event that is potentially life threatening or that results in death, hospitalization or lasting disability. If a trial has been designed in such a way that it is representative of reality, then the rate of serious adverse events in the trial should largely mirror that seen in the real world.

110 trials of RAAS-blockers were identified by the researchers. Of these, 11 were specifically designed to look at older people (i.e. didn’t recruit anyone under the age of 60). The data on serious adverse events from these 110 trials was extracted and compared to real world data on deaths and hospitalizations taken from a UK government funded database of 55,000 people living in Wales, who were being treated with RAAS-blockers. Deaths and hospitalizations are not exactly the same thing as serious adverse events (which as mentioned above also include “life threatening events”, and could for example include someone who is treated in an emergency department after a fall but not admitted to the hospital), but they’re close enough to allow a reasonable comparison.

So, what were the results?

Let’s begin with comparing the trials of older people with the “standard” trials. The relative rate of serious adverse events in the trials of older people was 76% higher than the rate in the standard trials. This shows the importance of including elderly people in drug trials – they are much more likely to experience adverse events of all kinds (including those actually caused by the drug being tested), and excluding them will therefore likely underestimate side effects.

Considering that many of the drugs in common use show marginal benefits at best (statins have, for example, only been shown to prolong life by a few days on average), this is important information. Why? Because a drug that is beneficial, on balance, to a fifty year old, who has a fully functioning kidney and liver, and is therefore unlikely to suffer side effects, could easily be harmful, on balance, to an 80 year old.

That’s why drug studies done on younger people should not be used to guide treatment of older people. No shock there. Everyone already knows that we shouldn’t be extrapolating results from one group to another (even though it happens all the time, as we’ve seen most recently with the covid vaccine trials).

Next we come to the more important, and perhaps more shocking finding.

The real world patients were between 300% and 400% more likely to experience a serious event than the participants in the trials! That is in spite of the fact that the trials, as mentioned above, were using a broader definition of what constituted a serious event. If the trials were representative of reality, then they should have a higher rate of events than is seen in the real world data. Instead they have a rate that is several times lower!

Interestingly, the trials of older people were just as far from the real world results as the trials of younger people. Clearly, doing trials on the elderly is not enough on its own to produce trials that are representative of reality. What’s happening here exactly?

There are three possible explanations, as far as I can see. The first explanation is that the trials are representative of reality, but that the Welsh die and are hospitalized at a rate that is several times higher than people in the countries where the studies were conducted. Many of the trials were conducted in the US, not in Wales. But Wales has a higher life expectancy than the United States, so that seems unlikely. I think we can discount that explanation.

The second explanation is that the trials are unrepresentative in so many different ways that just correcting the age issue doesn’t make a noticeable difference. That’s probably part of the explanation. The average age even in the trials of “older people” was 73, which isn’t very old from my perspective. And those 73 year olds included in the trials were probably at the healthier end of the spectrum.

The third, more sinister explanation, is that the pharmaceutical companies are hiding serious adverse events… But wait a minute, the trials are randomized and blinded, so the people running the drug trials have no way of knowing if someone experiencing a possible side effect is in the treatment group or the placebo group, right?

Yes, that’s right, so the easiest solution, if you want to avoid finding nasty side effects, is to not report them, regardless of which treatment group the participant is in. That will cut down on total adverse events in both groups, which will make any difference between the groups that does exist smaller in absolute terms, and also less likely to reach the level of statistical significance. Voila – the treatment group and the placebo group end up having similar rates of side effects, and the drug company can conclude that the drug is completely safe.

Is that what’s happened here? Are the pharmaceutical companies hiding adverse events? Well, it’s very strange that the real world data shows a rate of serious adverse events that is several times higher than is found in the trials. It’s hard to see how that massive difference could be explained in any other way.

So, how big a problem is this?

Big. Very big. It should shake the very foundations of evidence based medicine. If the drug trials and the real world data show such wildly different rates of adverse events, then it really begs the question how much we can trust the trials at all. It would be perfectly reasonable in this situation to say that all “evidence” produced by pharmaceutical companies is so suspect that it should be dismissed out of hand, and that only independently funded trials should be used as a basis for medical treatment decisions.

The problem with that is that it would mean saying goodbye to most of the trials that form the basis of modern medical treatment, and there is not much to replace them with. This issue could be solved over the longer term through large tax payer funded investments in new independent trials. But there’s no quick fix.

The problem is most acute when it comes to the many drugs in common use that only show marginal benefits, such as statins. If the rate of side effects is actually 300% to 400% higher than seen in the trials, then the harms of these drugs could easily outweigh the benefits. In other words, the cost-benefit calculation could shift entirely for many of the most commonly used drugs.

Ok, let’s wrap this up. What can we conclude?

Drug trials do no accurately represent rates of adverse events. It is likely that the true rate of side effects is often many times higher than that seen in drug trials.

July 19, 2021 Posted by | Corruption, Deception, Science and Pseudo-Science, Timeless or most popular | Leave a comment

COVID-19 Mortality Rate Among Children Is Even Lower Than Previously Thought

By Noah Carl • Daily Sceptic • July 19, 2021

We’ve known since the early weeks of the pandemic that age is the single best predictor of COVID-19 mortality, and that the risk of death for young people is vanishingly small.

A letter in the New England Journal of Medicine reported that zero Swedish children aged 1–16 died of COVID-19 up to the end of June 2020. And only 15 were admitted to the ICU, of whom four had a serious underlying health condition.

Of course, England is a much larger country than Sweden, and it’s been a whole other year since those Swedish data were collected. So how many English children have died of COVID-19?

In an unpublished study, Clare Smith and colleagues sought to identify the number of COVID-19 deaths among people aged under 18 between March 2020 and February 2021. They examined data from the National Child Mortality Database, which was linked to testing data from Public Health England and comorbidity data from national hospital admissions.

The structure of their dataset allowed the authors to distinguish deaths that were plausibly from COVID-19 and deaths that were merely with COVID-19.

3,105 under 18s died from all causes in England during the relevant time period. 61 of these involved people who had tested positive for the virus. However, the authors determined that only 25 were actually caused by COVID-19. And of the 25, 76% had a serious underlying health condition.

Given that an estimated 469,982 under 18s were infected with the virus up to February of 2021, the survival rate in this age-group (the inverse of the IFR) was 99.995%. What’s more, 99.2% of total deaths were caused by things other than COVID-19.

Smith and colleagues’ findings underline just how small a risk COVID-19 poses to young people, and hence – I would argue – why a focussed protection strategy was preferable to blanket lockdowns.

As early as 10th April 2020, Martin Kulldorff – co-author of the Great Barrington Declaration – published an article on LinkedIn titled ‘COVID-19 Counter Measures Should be Age Specific’.

Based on the data that were then available, he estimated one would need to stop 3.5 million children being exposed in order to prevent the same number of deaths as one could prevent by shielding 1,000 people in their 70s. He argued, therefore, that COVID counter-measures must vary by age.

A similar argument was made by George Davey Smith and David Spiegelhalter in a piece for The BMJ last May. These authors called for “stratified shielding”, while noting that this would “require a shift away from the notion that we are all seriously threatened by the disease”.

According to the medical researcher Russell Viner, who spoke to Nature, “There’s a general feeling among paediatricians that probably too many children were shielded during the first wave”. And the epidemiologist Elizabeth Whittaker said that efforts to shield children “have probably caused more stress and anxiety for families than benefit.”

In addition to “stress and anxiety”, there’s also the learning losses associated with months of online teaching. All this compared to the marginal impact closing schools had on the spread of COVID-19.

When we look back at the response to COVID, serious questions will have to be asked about the costs of lockdown, not only to society in general, but to young people in particular.

July 19, 2021 Posted by | Science and Pseudo-Science, Timeless or most popular | , | Leave a comment

The WHO Declares all PCR Tests at High CT to be Potentially 100% False Positives

By Judy Wilyman PhD | Vaccine Decisions | July 13, 2021

In December 2020 the WHO declared that any result from a RT-PCR test that was amplified at a high cycle threshold (CT) e.g. above 35 CT is potentially 100% false positive.  This leads us to question all the reported ‘cases’ of COVID19 disease  in Australia in 2020. This is because Australia has reported that it uses this PCR test at a CT of 40-45  and most of the reported ‘cases’ were people without symptoms. 

The question now is ‘What cycle threshold is the Australian government using in 2021?’ Has it been reduced at the same time as the vaccine was introduced to give the appearance that the vaccine has caused a decline in the cases of this disease?

The WHO says that in 2021 a manual readjustment of the PCR positivity threshold must be done to account for background noise in specimens with high cycle thresholds. 

There is no transparency in the use of this test that is now allowing government’s globally to claim that healthy people, without disease symptoms, are an asymptomatic case of disease. This also enables the government to claim that healthy people are a risk to society. This is criminal and this PCR test is not a diagnostic tool for any disease.

Many doctors and scientists are stating this and they are being ignored and censored. Here is the inventor of the test, Kary Mullis, also stating ‘it is not a diagnostic test‘. It should never be used when symptoms are not also present.

Traditionally doctors were taught to diagnose disease on a collection of symptoms and the PCR test was sometimes a supportive, but not a diagnostic, tool. This has all changed in 2020 to be able to claim that healthy people are now the cause of these diseases and this has been achieved without having to provide any supportive evidence for this claim.

In addition, it is these ‘cases’ that have been used by the government to enact the emergency powers. Yet the definition of a pandemic that is based on an increase in ‘cases’ of a disease has not been validated by the scientific community. It is not a scientific definition if it has not been validated by the community of scientists – not just elite individuals.

The case-tracing of healthy people with QR codes is fraudulent and it is enabling more ‘cases’ of disease to be obtained and more people to be locked up and falsely declared a ‘case’ of disease. This is industry-pseudoscience and it has all come about because the WHO allowed a small group of individuals, with financial conflicts of interest with industry, to adopt an unscientific definition of a ‘global pandemic’. 

This makes the use of the emergency powers invalid and all the directives that have been enacted to control this non-pandemic of a flu-like illness. Please read the full article describing the unscientific definition of a pandemic that has been used by governments and also watch the interview with Elizabeth Hart on Asia Pacific Today. This interview describes the full extent of the Australian government’s conflicts of interest in promoting an untested drug in the population. She also describes the complicity of the mainstream media and research institutions in this fabricated and well planned ‘pandemic’ event.

This crime against the population has also been perpetuated by governments deliberately suppressing the treatments for respiratory viruses that are known to be beneficial. Here is Craig Kelly presenting his evidence of this suppression in an empty Australian parliament. This picture illustrates the type of ‘democracy’ that we have in Australia today. The people’s voice is not being heard by our government.

In this video, Dr. David Martin explains to the International Criminal Court that there was nothing novel about the 2019 coronavirus. This is because it had been patented between 2008 – 2017 under gain of function research carried out in the US and in Wuhan, China. In addition, the fact that it was a mutated coronavirus means that humans would be expected to have some previous immunity to this virus because these are  a family of common respiratory viruses that cause the common cold.

It is now clear that this is a ‘pandemic’ in name only. This is why there is no evidence of enormous numbers of deaths and illness in the community. The WHO could not have declared this to be a ‘global pandemic’ in 2020, if the definition of a pandemic had not been changed in 2009.

The ‘cases’ of disease that the media is presenting are healthy people who have had a PCR test but have no symptoms. It is these cases in healthy people that are being used to close borders and quarantine healthy people. This is a media campaign using statistics out of context to encourage the community to accept the governments new regulations that restrict our fundamental rights and freedoms, ultimately harming our health and wellbeing.

July 19, 2021 Posted by | Deception, Science and Pseudo-Science | , | Leave a comment

Is the Delta variant spreading only in highly vaccinated countries? No.

Does Delta spread only in vaccinated countries? No. (Corona Realism)
Swiss Policy Research | July 18, 2021

A highly viral tweet by “Corona Realism” is making the following claim: “Something really odd is going on: In Europe we are seeing surges at many places where most of the population has already been vaccinated. At the same time, the 15 least vaccinated countries don‘t seem to face any problem. At some point, denying this problem will get painful.”

In reality, the “least vaccinated countries” shown above are simply the Eastern European countries, whose infection cycle has always been delayed compared to Western Europe. They already missed the first spring wave in 2020, which led to the notorious misinterpretation that they were protected by (useless) face masks. Back then, the chief pathologist of Bulgaria famously claimed that covid was a hoax; today, Bulgaria has one of the highest covid death rates in Europe. Vaccination rates in Eastern Europe are lower than in Western Europe primarily for economic reasons.

To make the deception work, “Corona Realism” had to leave out some highly vaccinated countries in Eastern Europe (notably Hungary, Poland and Czechia), whose infection rates are as low as in the rest of Eastern Europe; and he had to leave out the many countries with a low vaccination rate severely affected by Delta, notably Russia as well as many Asian and even African countries. In fact, in many countries with a low vaccination rate, Delta covid deaths have reached an all-time record level.

In conclusion, while many “public health experts” got almost everything wrong during the covid pandemic, skeptics should remain careful not to fall for some of the same fallacies.

See also: “Vaccine failure”? Not really. (updated section on several false claims)

Figure: Delta deaths in some Southeast Asian countries

Delta deaths in some Southeast Asian countries with a low vaccination rate.

Delta deaths in some Southeast Asian countries (OWD)

See also:

July 19, 2021 Posted by | Science and Pseudo-Science | | Leave a comment

The Origin of the Species – and of our Viral Issue!

The Fat Emperor | March 2, 2021

Pure gold is all I can say for Episode 110 – that’s what this conversation is!

The New York Times, WSJ and all of the media have mused about the origins of this virus – well here we explain the actual science and data, and what IT actually tells us 🙂

Jump straight into the origins discussion here: https://youtu.be/jPNu8sOU5RM?t=591

NOTE: My extensive research and interviewing/video/sound editing and much more does require support – please consider helping if you can with monthly donation or one-off payment – simply use the following link: https://www.paypal.com/donate?hosted_button_id=69ZSTYXBMCN3W

… or join up at my Patreon Link: https://www.patreon.com/IvorCummins

July 19, 2021 Posted by | Science and Pseudo-Science, Timeless or most popular, Video | | Leave a comment