Aletho News

ΑΛΗΘΩΣ

Omicron is Not Normal

Everything suggests this variant was leaked from a laboratory engaged in gain-of-function research

eugyppius | December 20, 2021

Omicron is not normal. No immediate progenitors are known; its closest relatives are viruses last seen in early- to mid-2020. The orthodox explanation for this awkward fact, is that it has spent the last 18 months lurking “in a geography with poor genomic surveillance … or … in a chronically infected individual.” The simpler explanation is that it leaked from a laboratory.

As el gato malo and others have indicated, evidence is strong that Omicron circulates preferentially in the vaccinated. In all likelihood, it is the result of gain-of-function research, in which it was passaged repeatedly through convalescent or vaccinated plasma, in the hopes of helping the virus evade acquired immunity. The purpose of this research would be to anticipate future immune-escape variants that vaccines might target.

Omicron carries a series of highly unlikely and suspicious mutations in its spike protein. It is hard to imagine that these mutations can have arisen via natural processes, because all but one of them are nonsynonymous – that is, they code for different amino acid sequences. Starkly mutated variants favoured by natural selection should have a great many meaningless synonymous mutations as well.

Omicron’s ancestors may have spent a significant amount of time adapting to mouse cells, before re-entering human hosts. Omicron appears selected to replicate primarily in the bronchial tract. Deeper in the human lung, it functions far less efficiently than Delta or the first strains from Wuhan. This is probably why it causes mostly mild illness, and it is reminiscent of techniques used to make live attenuated influenza vaccines safer for use in humans. Such vaccines are cold-adapted, that is, selected to circulate primarily in the cooler upper respiratory tract rather than in the warmer, more vulnerable lungs.

The balance of the evidence is that Omicron leaked from a lab engaged in SARS-2 vaccine research. There are many possibilities: It might represent a live, attenuated virus vaccine used informally among researchers, that mutated back to virulence and escaped; it might have been released accidentally; it could even be an attempt to develop a self-spreading vaccine to immunise animals or third world populations.

December 20, 2021 - Posted by | Science and Pseudo-Science |

1 Comment »

  1. Omicron… anagram of Oncomir:

    An oncomir (also oncomiR) is a microRNA (miRNA) that is associated with cancer. MicroRNAs are short RNA molecules about 22 nucleotides in length. Essentially, miRNAs specifically target certain messenger RNAs (mRNAs) to prevent them from coding for a specific protein. The dysregulation of certain microRNAs (oncomirs) has been associated with specific cancer forming (oncogenic) events. Many different oncomirs have been identified in numerous types of human cancers.[1]

    The first link between miRNA and the growth of cancer was reported in 2002 when researchers observed a down-regulation of miR-15a and miR-16-1 in B-cell chronic lymphocytic leukemia patients.[6] The term is a portmanteau, derived from “oncogenic” + “miRNA”, coined by Scott M. Hammond in a 2006 paper characterizing OncomiR-1

    from wankipedia

    Like

    Comment by Richard Jones | December 21, 2021 | Reply


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.