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Dr. Fauci Backed Controversial Wuhan Lab with Millions of U.S. Dollars for Risky Coronavirus “Gain of Function” Research

By Fred Guterl | Newsweek | April 28, 2020

Excerpts:

But just last year, the National Institute for Allergy and Infectious Diseases, the organization led by Dr. Fauci, funded scientists at the Wuhan Institute of Virology and other institutions for work on gain-of-function research on bat coronaviruses.

In 2019, with the backing of NIAID, the National Institutes of Health committed $3.7 million over six years for research that included some gain-of-function work. The program followed another $3.7 million, 5-year project for collecting and studying bat coronaviruses, which ended in 2019, bringing the total to $7.4 million.

Many scientists have criticized gain of function research, which involves manipulating viruses in the lab to explore their potential for infecting humans, because it creates a risk of starting a pandemic from accidental release.

The NIH research consisted of two parts. The first part began in 2014 and involved surveillance of bat coronaviruses, and had a budget of $3.7 million. The program funded Shi Zheng-Li, a virologist at the Wuhan lab, and other researchers to investigate and catalogue bat coronaviruses in the wild. This part of the project was completed in 2019.

A second phase of the project, beginning that year, included additional surveillance work but also gain-of-function research for the purpose of understanding how bat coronaviruses could mutate to attack humans. The project was run by EcoHealth Alliance, a non-profit research group, under the direction of President Peter Daszak, an expert on disease ecology. NIH canceled the project just this past Friday, April 24th, Politico reported. Daszak did not immediately respond to Newsweek requests for comment.

The project proposal states: “We will use S protein sequence data, infectious clone technology, in vitro and in vivo infection experiments and analysis of receptor binding to test the hypothesis that % divergence thresholds in S protein sequences predict spillover potential.”

In layman’s terms, “spillover potential” refers to the ability of a virus to jump from animals to humans, which requires that the virus be able to receptors in the cells of humans. SARS-CoV-2, for instance, is adept at binding to the ACE2 receptor in human lungs and other organs.

According to Richard Ebright, an infectious disease expert at Rutgers University, the project description refers to experiments that would enhance the ability of bat coronavirus to infect human cells and laboratory animals using techniques of genetic engineering. In the wake of the pandemic, that is a noteworthy detail.

A decade ago, during a controversy over gain-of-function research on bird-flu viruses, Dr. Fauci played an important role in promoting the work. He argued that the research was worth the risk it entailed because it enables scientists to make preparations, such as investigating possible anti-viral medications, that could be useful if and when a pandemic occurred.

The work in question was a type of gain-of-function research that involved taking wild viruses and passing them through live animals until they mutate into a form that could pose a pandemic threat. Scientists used it to take a virus that was poorly transmitted among humans and make it into one that was highly transmissible—a hallmark of a pandemic virus. This work was done by infecting a series of ferrets, allowing the virus to mutate until a ferret that hadn’t been deliberately infected contracted the disease.

The work entailed risks that worried even seasoned researchers. More than 200 scientists called for the work to be halted. The problem, they said, is that it increased the likelihood that a pandemic would occur through a laboratory accident.

April 29, 2020 Posted by | Deception, Science and Pseudo-Science, Timeless or most popular | , , | Leave a comment

Vitamin D Status and Viral Interactions… The Science

Ivor Cummins | April 27, 2020

Episode 73: Another one for Science and Data-Centric people everywhere

– a review of recent publications on Vitamin D versus Virus Infection severity of outcome

– fascinating early data emerging

– if it bears up in continued studies, this could have major implications for how we deal with this difficult situation

My 2014 Vitamin D talk here: https://www.youtube.com/watch?v=v3pK0…

Please support this free podcast by watching ExtraTimeMovie.com and sharing it to help others!

April 28, 2020 Posted by | Science and Pseudo-Science, Timeless or most popular, Video | Leave a comment

Why Outside Air is Safe and Park Closures Should End

Cliff Mass Weather Blog | April 18, 2020

During the past month, the fear of coronavirus had spurred political leaders to close parks and nature areas throughout the country.

In Washington State, all state parks and state lands managed by the Department of Natural Resources are closed through at least May 4. Here in Seattle, all major city parks were closed last weekend and parking lots for city parks are still shuttered. Picnicking, barbecuing, and any sports are illegal in Seattle parks. In California, hundreds of state parks, including many major beach areas, have been closed, and parking has been blocked off for all state recreation facilities.

All of these closures are predicated upon the assumption that coronavirus infection is a serious threat in outside air and that virus spread is significant outdoors. As documented in this blog, such an assumption is not consistent with the best science. Furthermore,  there is strong evidence that restriction of public access to parks and natural areas threatens both the physical and mental well being of the population and thus is counterproductive. Many politicians claim that parks must be closed to prevent large groups from gathering and spreading the virus. As we will see, such worries appear to have little basis in fact.

Torrey Pine Beach north of San Diego Is closed

Is Outside Air Safe?

After searching through the literature and talking to a number of doctors and researchers, I could not find a single paper suggesting significant outdoor transmission of COVID-19 or any coronavirus. But there is a huge literature and long historical experience suggesting that outside air is immensely safer than indoor air within constrained spaces. Here are a few examples and some quotes from medical experts on this point:

  • Qian et al., 2020: Examined 1245 confirmed cases in 120 cities in China and identified only a single outbreak in an outdoor environment, which involved two cases.
  • Nishiura et al., 2020: Transmission of COVID-19 in a closed environment was 18.7 times greater compared to an open-air environment (95% confidence interval).
  • Lidia Morawska, professor and director of the International Laboratory for Air Quality and Health at Queensland University of Technology in Brisbane, Australia.”: Outdoors is safe, and there is certainly no cloud of virus-laden droplets hanging around… Firstly, any infectious droplets exhaled outside would be quickly diluted in outdoor air, so their concentrations would quickly become insignificant. “In addition, the stability of the virus outside is significantly shorter than inside. So outside is not really a problem… It is safe to go for a walk and jog and not to worry about the virus in the air”

Influenza patients were moved into the sunny, outside air to promote recovery during the 1918-1919 pandemic.

  • There is deep experience during other pandemics that placing patients outdoors greatly enhanced their recoveries and lessened spread to others. In fact, during some pandemics (like 1918-1919) open-air hospitals were built and patients were moved outside into the sun, with very positive impacts. To quote one paper on the subject (“The Open Air Treatment of Pandemic Influenza”, which documented the reduction of mortality and morbidity in the open air: “more might be gained by introducing high levels of natural ventilation or, indeed, by encouraging the public to spend as much time outdoors as possible.”
  • There is an extensive literature that ultraviolet radiation from the sun can quickly degrade the viability of viruses in the air (e.g., Schuit et al. 2020: The Influence of Simulated Sunlight on the Inactivation of Influenza Virus in Aerosols). As noted by Lytle et al., 2005: “Sunlight or, more specifically, solar UV radiation (UV) acts as the principal natural virucide in the environment.” Duan et. al. 2003 found that “UV irradiation can efficiently eliminate the viral infectivity”
  • A fascinating study of virus transmission in dorms at the University of Maryland compared students in rooms with poor ventilation, with those who kept their windows open all the time (Zhu et al., 2020).  Those with open windows had one-fourth the rate of respiratory infections. Some did complain of being cold, though.
  • Virus particles rapidly disperse in the open air as noted by Case Western Reserve University Hospitals infectious disease specialist Dr. Amy Edwards: “When someone coughs or sneezes, most of the virus drops to the ground within 6 feet pretty quickly. That’s why doctors recommend social distancing. If a few particles remained in the air, they would be killed off by UV light in the sun, or blown away by the wind”

I could quote a lot more literature and from additional specialists, but you get the point. Being in fresh, outside air, particularly when the sun is out, is clearly a good place to lessen one’s exposure to COVID-19.

The risk of transmission of COVID-19 is extraordinarily less in outside air compared to within buildings. There is essentially no background concentrations of the virus in outside air. Ultraviolet radiation from the sun is destructive to the virus. There is rapid dispersion of any source of virus (e.g., an infected coughing individual) by the wind in the vast outside volume of air. And there is a substantial literature that concentration matters: the more exposure to viral particles the greater the chance of infection. Viral concentrations will be very low outside, if they are measurable at all.

Another issue is humidity. Viral transmission is degraded by high humidities and enhanced by lower humidities (check out this excellent recent review article: Moriyama et al. 2020); several papers suggest that relative humidities above 40% degrade transmission. During the cool season, humidity inside building tends to be very low (check my earlier blog for an explanation), but outside humidities are generally much higher. For example, below is a plot of the relative humidity in Seattle over the past three years. Outside relative humidity only rarely drops below 40% around here.  Inside RH is often below 40% during the cool season.

Recently, there has been a lot of media attention regarding a simulation of particle dispersion from a coughing runner, with recommendations not to run directly behind him/her and particularly in the wake region behind the runner. There was some dramatic imagery (see below), but the risk from sick runners is really quite small.

First, there are not many runners coughing and sneezing while running–when someone is sick with the virus they have great fatigue and if they were asymptomatic carriers they would not be coughing! (Note: there are some folks that cough after intense exercise). Furthermore, the large virus-laden droplets tend to fall quickly and the smaller particles/droplets tend to follow the streamflow around an obstacle (that’s you). Most importantly, the droplets ejected from a sick runner would rapidly disperse in the free atmosphere and the UV radiation would work to lessen the viability of a virus. Yes, there is a slipstream of air immediately behind a runner in which concentrations could be greater…. but how many people are running immediately behind a sick runner? Even in the video, little of the particles reach the face of the runner following immediately behind. Folks, this is a very small risk.

So let’s get back to the policy decision to ban folks from parks and why it is illogical and contrary to common sense.

Hopefully, you are convinced that outside air is immensely more healthful with far less COVID-19 risk than the air we breathe inside of buildings. You really want folks outside for that reason alone.

But what about social distancing? If that is good, you want folks to spread out as much as possible. Thus, they should be ENCOURAGED to get their fresh air in vast open public spaces and particularly ones with lots of air motion (i.e. wind).

But yet that is exactly the opposite of what our political leadership is doing. Here in Seattle, the Parks Department closed the largest parks in the city (like Magnuson, Lincoln and Discovery) last weekend, parks that afford great opportunities for social distancing (see map). Many of these large parks (red X in the above figure) are near the water and experience stronger winds that are  particularly favorable for virus dispersal. In contrast, the city left the smaller parks open, concentrating folks in small areas. Just as bad is the closing of park parking lots, which forced folks to leave their cars outside of parks and to walk in narrow corridors (less social distancing) to enter the parks.

Magnuson Park was closed and everyone is forced to walk on the crowded path to the left.

In California, vast beach areas are closed, again forcing folks to stay indoors or crowd onto limited walkways.

All these park closures are based on fears of transmission within groups enjoying the parks. But such closures do not make sense. First, there is little evidence of viral spread in outdoor spaces, even when crowded. Second, there is little evidence for such crowding in Washington State and California parks in other than the most isolated incidents. I have been to several Seattle parks during the past weeks– folks are generally careful and respectful, without large collections of folks in close proximity. Obviously, park officials can make it clear that closely packed large crowds are not appropriate and that there will be warnings and citations if such crowds occur. To put it succinctly, park closure is a solution in search of a problem that has never been shown to exist. And it hurts exactly the people it is meant to help.

More Issues

Going to parks is extraordinarily good for physical and mental health. Being outside exposes folks to the sun’s UV rays that facilitate production of vitamin D, which bolsters the immune system and reduces the chance of infection by COVID-19 and other pathogens. Recently, I got a call from a UW professor of medicine who is working on exactly this important relationship with COVID (he needed global UV/solar radiation data), confirming the above. Vigorous exercise and even walking enhance the immune system, reducing chances of infection. And exercise and fresh air have a very positive effect on mood, reducing stress and anxiety–both of which weaken the immune system,

And in a progressive city like Seattle, or in the progressive states of Washington or California, there are simple equity ideas that should be compelling. Closing parks or making entry difficult hurts low income people the most. Folks that live in small apartments or in crowded environments greatly enjoy the physical and emotional release of our wonderful large parks. They are the ones who are most deprived by the park closings, both mentally and physically, in comparison to those with large homes and extensive garden areas. And the closing of parking lots deprives the elderly and physically handicapped from the healthful conditions in our parks and the emotional salve of enjoying the outdoors. I have noted the demographic shift in the park when the parking lots were closed.

In some ways, this is all about risk. There is an extraordinarily small risk of catching COVID-19 while enjoying parks and natural areas. I mean really, really small. But park closures provide substantial risks that clearly threaten one’s physical and mental health. Our society is not particularly good in qualifying and acting upon risks, and the park closures are a prime example of this failure.

Sunset at Shoreline’s Richmond Beach Park.

Parking is closed and many cannot enjoy this view anymore.

Governors Inslee, Cuomo, and Newsom have all stated that in dealing with the COVID-19 crisis it is essential to “follow the science.” It is time that they follow their own advice, reopening all the parks and nature areas, including the restoration of all parking facilities and access.

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Addendum: A few commenters (and some politicians) have said that the parks should be closed because a few individuals did not practice sufficient social distancing in their evaluation. So should everyone be punished and denied access to the parks because of a very small minority (the overwhelming number of park visitors are not gathering in groups)?

Such communal punishment seems something out of a non-democratic society. Plus, the dangers of isolated groups in the outside air is totally speculative and not based on any evidence.   Consider the situation on the highways. Because some people are speeding and endangering others, do we stop EVERYONE from driving. Of course not. We warn them and give them tickets. We can do the same thing in parks.

PSS: There are reasonable measures that could be done in parks, like closing active playgrounds and perhaps the bathrooms. Places where many people are physically touching the same objects.

April 27, 2020 Posted by | Civil Liberties, Science and Pseudo-Science | , | Leave a comment

Dr SHIVA LIVE: How Vitamin D Defends YOU – More EVIDENCE & MSM Forced to Admit Truth

Dr. Shiva Ayyadurai | April 20, 2020

Learn more about my technology #CytoSolve that helps discover molecular pathways. #VitaminD #TruthFreedomHealth

——-

CytoSolve provides the world’s first computational systems biology platform for scalable integration of molecular pathway models to enable predictive and quantitative understanding of complex biomolecular processes and diseases to determine risk, toxicity, and efficacy UPFRONT in the product development process. CytoSolve’s technology platform is enabling innovative and visionary manufacturers to develop and deliver products to end-consumers that truly advance health and well-being, faster, cheaper, and safer. http://www.CytoSolve.com

April 27, 2020 Posted by | Corruption, Deception, Science and Pseudo-Science, Timeless or most popular, Video | Leave a comment

Oregon State University researcher: Vitamins C, D can help prevent COVID-19

“The stakes are huge”

By Whitney Woodworth | Salem Statesman Journal | April 23, 2020

Supplements containing vitamins C and D, along with other micronutrients [zinc], can be a “safe, effective and low-cost” means to fight off COVID-19 and other acute respiratory tract diseases, according to an Oregon State University researcher.

Adrian Gombart of OSU’s Linus Pauling Institute, along with his collaborators at universities across the world, said public health officials should issue a clear set of nutritional guidelines to complement the existing advice about washing hands to prevent the spread of infections.

Findings were published Thursday in the peer-reviewed journal Nutrients. … continue

April 26, 2020 Posted by | Science and Pseudo-Science, Timeless or most popular | | Leave a comment

Scientific Study Traces the Evolution and Migration of SARS-CoV-2. Where did the Virus Originate?

Review of an Important Peer Reviewed PNAS Study entitled Phylogenetic network analysis of SARS-CoV-2 genomes, by Peter Forster, Lucy Forster, Colin Renfrew, and Michael Forster

By Allen Yu | Global Research | April 24, 2020

Phylogenetic network analysis of SARS-CoV-2 genomes by Peter Forster, Lucy Forster, Colin Renfrew, and Michael Forster published by the Proceedings of the  National Academy of Sciences of the United Sciences of America (PNAS)focuses on a study of the genomes of 160 covid-19 patients.

As readers may know, viruses are RNA-based entities that periodically and regularly undergo mutations. One can study these mutations and almost like clockwork trace their evolution – i.e. their lineage and migration pattern.

The authors specifically employed a methodology known as “character-based phylogenetic networks”. The technique has been used as the “method of choice” to reconstruct prehistoric human population movements, language evolution, various ecological studies, and some 10,000 phylogenetic studies of diverse organisms – and now virology.

This is an early study – the sample size is only 160 humans – with 100 types. However, the results are stunning. Among the key conclusions:

  1. There are three major types of coronaviruses, A, B, and C, with type A being the ancestor of SARS-CoV-2 in humans and showing 96.2% similarly to a particular strain of virus in bats.
  2. Most of the viruses in China and Wuhan are of type B while most of the viruses found in America, Europe and Australia are of type A and C. Type C is not found in Mainland China but is found in significant numbers in Hong Kong, S. Korea, and Taiwan.
  3. While Type B is found in large numbers across Mainland China (including Wuhan), it is not found in significant numbers around the rest of the world.
  4. The methodology used was successfully used to trace several clinically verified cases of virus travel from Wuhan out to various nations, including Brazil and Italy. As such, the authors conclude the “character-based phylogenetic networks” methodology was useful and appropriate for studying the spread and evolution of the coronavirus.
  5. Yet, according to the methodology, the earliest sample of virus studied – collected on December 24 2019 in Wuhan – WAS NOT close to being the ancestor of SARS-CoV-2.

According to the authors:

In a phylogenetic network analysis of 160 complete human severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) genomes, we find three central variants distinguished by amino acid changes, which we have named A, B, and C, with A being the ancestral type according to the bat outgroup coronavirus. The A and C types are found in significant proportions outside East Asia, that is, in Europeans and Americans. In contrast, the B type is the most common type in East Asia, and its ancestral genome appears not to have spread outside East Asia without first mutating into derived B types, pointing to founder effects or immunological or environmental resistance against this type outside Asia. (To read the complete scientific report in pdf click here)

Some observations…

First, most of the viruses in the West do not seem to have arisen from China. The authors identified Type B as the main virus type found in Mainland China, with that Type mostly confined to Mainland China and Types A and C predominant outside China – including U.S., Europe and Australia.

Two reasons given for why Type B variants (“China’s virus,” if you must) did not expand much beyond Mainland China: one being “complex founder scenario” and second “the ancestral Wuhan B-type virus is immunologically or environmentally adapted to a large section of the East Asian population, and may need to mutate to overcome resistance outside East Asia.”

Since I have yet to see any reputable studies that shows any strains of the coronavirus having any affinity or dislike to any ethnicity of people, let’s focus on “complex founder scenario” and “environment” resistance.

The authors have noted many perplexities in the study. But if we consider the possibility that coronavirus did not originate in Wuhan, those perplexities all go away. More specifically, let’s presume a scenario where the virus was already circulating under the radar in the West and were carried to Wuhan in December or some time before, where it then spread locally within China.

Consider the fact that the authors had noted that Type B variants outside China did not show the “one-month” variations that would have been expected were Type B variants and descents to have traveled out of China to infect the rest of the world.

But if Type B variants – including Type C “descendants” – were already communally established and transmitted outside China, then this paradox easily goes away.

Assuming the virus to have been brought to Wuhan instead of originating from Wuhan would also constitute a “complex founding scenario” that the author hypothesized could solve the riddle.

This assumption also provides an explanation for the “environmental resistance” the author hypothesized. If the virus arrived in Wuhan with the Chinese authorities quickly closing down the city soon afterwards, the virus would not have had chance to spread to the rest of the world. The Chinese government’s shutting down of Wuhan in January could easily form the “environmental resistance” the authors hypothesized for the Type B virus.

Finally, it is important to note that in this study, of the 160 samples, most are from patients in China, only a few from outside Asia. In this study, the authors had tentatively labelled Type C as a descendant of Type B found in China. But while Type B is found mostly in Wuhan, it has also been found in significant numbers outside China. As more data from outside China comes live (one hopes soon), the same methodology will probably reveal that the predecessor to Type B and Type C arose outside not inside China. Type A and Type C thus all arose outside China and independently of China.

While the current study is China-centric (most data are from China), it already has established that the virus did not arise in Wuhan. The authors noted importantly in the data supplement section, “the oldest isolate from 24 December 2019 (brown node, week 0) lies diagonally opposite to the bat virus outgroup root.”

As we get more data, studies such as this will shed a lot of light on the origins of the coronavirus. It is really too bad, such a shame that the U.S. and Europe has missed such critical times testing and tracking the viral flow. It is worth noting that U.S. officials are blaming China for the virus. But even with limited data, the authors have been able draw some preliminary conclusions regarding the geographic origins of the virus.

***

The title of the PNAS article is:

Phylogenetic network analysis of SARS-CoV-2 genomes (pdf)

authors: Peter Forster , Institute of Forensic Genetics, Münster, Germany, Lucy Forster, McDonald Institute for Archaeological Research, University of Cambridge, Colin Renfrew, Fluxus Technology Limited, Colchester, UK, and Michael Forster, Institute of Clinical Molecular Biology, Christian-Albrecht University of Kiel, Germany

***

Copyright © Allen Yu, Global Research, 2020

April 25, 2020 Posted by | Science and Pseudo-Science | | Leave a comment

Methane forms under space conditions in laboratory

TALLBLOKE’S TALKSHOP | April 20, 2020

It’s now thought that methane, aka natural gas, existed even before planet formation, which looks like the final nail in the coffin for the idea that it should be regarded exclusively as a ‘fossil’ fuel.

– – –

An international team of astronomers has shown in a laboratory at Leiden University (the Netherlands) that methane can form on icy dust particles in space, reports Phys.org.

The possibility had existed for quite some time, but because the conditions in space were difficult to simulate, it was not possible to prove this under relevant space conditions.

The researchers will publish their findings Monday evening in the journal, Nature Astronomy.

Methane on Earth

Methane, known to us as the main compound of natural gas, is one of the simplest hydrocarbons. It consists of a carbon atom with four hydrogen atoms: CH4. On Earth, we mainly know methane as a flammable gas that forms from decaying organic material.

Methane in space

Methane is also available in space as a gas, liquid, or ice. For example, Neptune and Uranus contain, in addition to hydrogen and helium, mainly methane gas. Saturn’s moon, Titan, the only moon in our solar system with a dense atmosphere, does not rain water but liquefied methane.

Outside of our solar system in interstellar space, methane ice is one of the ten most abundant ices to be detected.

Ice grain dust as hangout

The prevailing opinion about how methane is created in space is that CH is formed first, then CH2, CH3, and finally CH4. In the gas phase, this reaction is slow. But because methane is formed on an icy dust grain, the grain itself helps speed-up the formation process.

For example, dust grains provide a ‘hangout’ spot for atoms, increasing their likelihood to meet each other in the vastness of space. They can also absorb the energy that is produced from chemical reactions that would otherwise break apart molecules, such as methane.

Creating methane in ‘space lab’

Researchers from the Laboratory for Astrophysics at Leiden Observatory (Leiden University, the Netherlands) have now for the first time succeeded in making methane under relevant space conditions. They let hydrogen atoms collide with carbon atoms at minus 263 degrees Celsius (-442 °F, 10 K) in an ultrahigh vacuum environment on an ice-cold surface.

The researchers had previously succeeded in making water (H2O) and ammonia (NH3) in a similar way. They did so by letting oxygen and nitrogen atoms react with hydrogen atoms.

However, reactions with carbon atoms proved to be more challenging. That is because carbon is very sticky, which makes experimenting with it very difficult.

Danna Qasim, Ph.D. student at Leiden Observatory and lead author of the scientific publication in Nature Astronomy, adds: “It is difficult to conduct an experiment with carbon atoms. Carbon likes to stick, so it is challenging to produce a controlled beam of pure carbon atoms. At the same time, you have to make sure that after an experiment, your entire setup is not completely covered with carbon.”

The researchers were able to vary the conditions in their experiments. This allowed them to investigate exactly how and how efficiently methane can be formed by the reaction of carbon and hydrogen atoms.

Full report here.

 

April 20, 2020 Posted by | Malthusian Ideology, Phony Scarcity, Science and Pseudo-Science, Timeless or most popular | Leave a comment

‘Grave concerns’ about Covid-19 immunity passports

By Tom WHEELDON | France 24 | April 16, 2020

Trapped between the competing urgencies of saving lives from Covid-19 and avoiding economic calamity, some government officials have mooted “immunity passports” as a way through the impasse. But experts told FRANCE 24 that the necessary antibody testing is not reliable enough – and even if the scheme were feasible, it could create a dangerous incentive for some to acquire the virus in order to qualify for some to acquire the virus in order to qualify for the passport.

The global tally of confirmed coronavirus cases surpassed 2 million on Wednesday – a day after researchers at the Harvard School of Public Health warned that the US may need to keep some social distancing measures until 2022, while the IMF predicted that, thanks to “the Great Lockdown”, the world will suffer the worst recession since the Great Depression.

Anxious about both the unfolding economic disaster and the risk of Covid-19 resurging if lockdowns are reversed prematurely, some officials in hard-hit countries have suggested that a system of immunity passports could be a route out of the coronavirus crisis – for some at least. The idea is that people who have already had the disease and thereby gained immunity could be given permits to live their lives mostly like they did before the pandemic.

Shortly after emerging from self-isolation after testing positive for Covid-19, the UK’s Health Secretary Matt Hancock announced in early April that the British government was considering an “immunity certificate” system to allow those who qualify to “get back as much as possible to normal life”.

Paris Mayor Anne Hidalgo has also given the idea her backing – putting it in a list of proposals for returning to business as usual in the City of Lights that she sent to the French government. On the other side of the Atlantic, Anthony Fauci, the director of the US National Institute of Allergy and Infectious Diseases, told CNN that immunity passports are “being discussed” in the Trump administration. “It might actually have some merit under some circumstances,” he added.

Antibody tests ‘not sufficiently accurate’

Immunity passports would require tests for antibodies specific to Covid-19, which would be different from those used to discern whether or not people currently have the virus. The problem is that, as things stand, these tests “are not sufficiently accurate for individual immunity passports”, which means that “we are still a long way off it being useful to test individuals with these methods”, said Claire Standley, an assistant professor at Georgetown University’s Center for Global Health Science and Security.

A major reason why such tests look likely to be ineffective, Standley explained, is that they do not seem specific enough to avoid mistaking a similar virus for Covid-19: “There may be cross-reactivity between the antibodies for SARS-CoV-2 [Covid-19] and other circulating coronaviruses – including those that cause common colds – meaning a positive result might not indicate past exposure to SARS-CoV-2 but maybe another coronavirus instead.”

As well as flagging up people who have recovered from ailments that merely seem similar to Covid-19, Standley said these tests also have a problem in failing to detect some people who have experienced a minor form of the virus: “High false negative rates (lack of sensitivity) of the test mean that those currently available are not recommended for patient-level clinical diagnosis; unless the sensitivity improves, these tests may also not be effective in identifying people who have recovered from mild cases of Covid-19, and thus may have lower levels of antibodies in their blood.”

Immunity for less than one year?

Issues with the accuracy of testing equipment may be solved through rapid technological advances as the world’s scientists focus their energy and resources on tackling the coronavirus pandemic. However, one potentially intractable problem with immunity passports is that immunity might not last terribly long.

“At this point, the virus has been widely circulating in Europe and North America only for a couple of months, and so that is all the information we have – we will know in a year if immunity lasts a year; we will know in two years if immunity lasts two years,” noted Abram Wagner, an assistant professor of epidemiology at the University of Michigan. “From past research into other coronaviruses, immunity was not long lasting, and I would not be surprised if, for most people, immunity lasted less than one year.”

In addition to these scientific hindrances standing in the way of immunity passports, there are worries about the social implications: “I suspect many people will be resentful if others were able to return to work and make money because they had an immunity passport,” Wagner put it.

“I have grave concerns about how these types of schemes could be implemented equitably and fairly, even assuming a reliable antibody test were available, and more known about the length of immunity and how protective it is,” Standley added.

In particular, she said, immunity passports threaten to accentuate inequality between the haves and have-nots, which lockdowns have already intensified: “If the tests need to be purchased, this could further exacerbate disparities between those who can afford the tests (and who may already have been able to work from home/maintain an income during lockdown) versus those who cannot, and thus would be further barred from re-entering the workforce.”

Another unsettling point Standley raised is that immunity passports could create a perverse incentive to contract the coronavirus: “In an effort to return to work, or allow their children back to school, will the promise of an immunity passport make people behave less responsibly, and risk infection, in order to end up with a positive antibody test?”

In this way, an idea touted as a way of giving people their lives back could disadvantage those who have acted most virtuously, Standley warned: “The scheme would potentially punish those citizens who have behaved responsibly and tried their best to reduce their own risk of exposure and that of transmission within their communities.”

April 17, 2020 Posted by | Civil Liberties, Science and Pseudo-Science | Leave a comment

The Controversy Over Who Is Responsible for Coronavirus Is Heating Up

By Paul Craig Roberts • Institute for Political Economy • April 14, 2020

Let’s hope the Neoconservatives and American presstitutes don’t add a conflict with China to the ongoing virus and economic threats.

First, is the virus a bioweapon? Second who is responsible?

Two sources concluded that the virus was a bioweapon. One is Francis Boyle, who drafted the US implementing legislation for the Biowarfare Convention that became US law in, I believe, 1989. Boyle says the US government violates the law and has 13,000 scientists working on biowarfare research. Boyle said in February that the aerosol gain-of-function of the virus was done at a UNC lab at which a Wuhan scientist was present, and the HIV features were done in Australia where a Wuhan scientist was present. He says the scientists took the work back with them and the result was Covid-19. Also in February or March a scientific paper by scientists in India concluded that the virus was man-made. Their paper was taken down without explanation.

A top virologist, whose statements to the Belgium government concerning the inadequacy of the government’s response to the virus I have posted on my website, tells me that the Indian scientists were mistaken, and that the virus is naturally evolved. As he is not involved in bioweapons work, I do not think he is covering up illegal activity by US and Chinese governments. He shows in his public concern every indication of being a highly principled person of unquestioned ability and character. Moreover, his position seems to be widely shared among experts.

As for responsibility, it seems both China and the US are responsible. It is clear from news reports that the US contributed millions of dollars to the Wuhan level 4 lab for research having to do with bats and coronavirus. What this research was, we don’t know. We only know what they say. But the US government was aware of the bat coronavirus research and helped to fund it. There was also a report that after the virus outbreak the president of China suddenly removed the top people at the Wuhan facility and put in charge a woman who was an expert virologist. Chinese president XI thought something had gone wrong at the lab and said it was the duty of the government to protect the people.

We also know that various Chinese officials and press said the Americans had brought the virus with them when they came to Wuhan to participate in the military games. The Chinese did not mean on purpose, but that someone among the US team was infected without having symptoms, often a feature of the virus. There was some discussion in which US health officials seemed to acknowledge that the virus might have been active in the US before it broke lose in a mass way.

We also know that Trump and now the neoconservative warmongers are blaming China for keeping quiet too long about the virus. This claim as far as I can tell is false. It seems to be mainly propaganda against China.

We also have had reports that a US military lab in Texas was suddenly closed out of pathogen concerns by the Obama regime.

How all this fits together or doesn’t I don’t know.

As the Democrats are blaming Trump for the virus, Trump blames China as that aligns the Democrats with the “enemy” China and is a way of showing that the Democrats are covering up for “Communist China” by shifting the blame to the president of the US.

The politics of the virus will make it difficult for the truth to emerge.

April 14, 2020 Posted by | Deception, Mainstream Media, Warmongering, Militarism, Science and Pseudo-Science | , , | Leave a comment

Vaccines and the Liberal Mind

By Robert F. Kennedy Jr. | Common Dreams | June 12, 2018

Late last year, Slate published an investigative report detailing how pharmaceutical giant, Merck, used “flawed” and “unreliable” pre-licensing safety studies to push through approval of its multi-billion-dollar bonanza, the HPV vaccine. For veteran safe vaccine advocates, like myself, the most shocking aspect of the expose was that Slate published it at all. Slate and other liberal online publications including Salon, Huffington Post and The Daily Beast customarily block articles that critique vaccine safety in order, they argue, to encourage vaccination and protect public health.

Motivated by this noble purpose, the liberal media—the supposed antidote to corporate and government power—has helped insulate from scrutiny the burgeoning vaccine industry and its two regulators, the U.S. Food and Drug Administration (FDA) and Center for Disease Control and Prevention (CDC). Both agencies have pervasive and potentially corrupting financial entanglements with the vaccine manufacturers, according to extensive congressional investigations.

Ironically, liberals routinely lambaste Pharma, and its FDA enablers for putting profits over people. Recent examples include Vioxx (100,000 injured—Merck paid more than $5 billion in fines and settlements), Abilify (Bristol Meyers Squibb paid $515 million for marketing the drug to nursing homes, knowing it can be fatal to seniors), Celebrex and Bextra (Pfizer paid $894 million for bribing public officials and false advertising about safety and effectiveness) and, of course, the opioid crisis, which in 2016 killed more Americans than the 20-year Vietnam War.  What then, makes liberals think that these same companies are immune from similar temptations when it comes to vaccines? There is plenty of evidence that they are not. Merck, the world’s largest vaccine maker, is currently fighting multiple lawsuits, brought by its own scientists, claiming that the company forced them to falsify efficacy data for its MMR vaccine.

The Slate article nowhere discloses that FDA licenses virtually all vaccines using the same mawing safety science deficiencies that brought us Gardasil. FDA claims that “vaccines undergo rigorous safety testing to determine their safety.” But that’s not true. FDA’s choice to classify vaccine makers as “biologics” rather than “drugs” opened a regulatory loophole that allows vaccines to evade any meaningful safety testing. Instead of the multi-year double-blind inert placebo studies—the gold standard of safety science—that the FDA requires prior to licensing other medications, most vaccines now on the CDC’s recommended childhood vaccine schedule were safety tested for only a few days or weeks. For example, the manufacturer’s package insert discloses that Merck’s Hep B vaccine (almost every American infant receives a Hep B shot on the day of birth) underwent, not five years, but a mere five days of safety testing. If the babies in these studies had a seizure—or died—on day six, Merck was under no obligation to disclose those facts.

Furthermore, many vaccines contain dangerous amounts of known neurotoxins like mercury and aluminum and carcinogens like formaldehyde, that are associated with neurodevelopmental disorders, autoimmune problems, food allergies and cancers that might not be diagnosed for many years. A five-day study has no way of spotting such associations. Equally shocking, FDA does not require vaccine manufacturers to measure proposed vaccines against true inert placebos, further obscuring researchers’ capacity to see adverse health effects and virtually guaranteeing that more subtle injuries, such as impaired immune response, loss of IQ or depression, will never be detected—no matter how widespread. Furthermore, the CDC has never studied the impacts on children’s health of combining 50 plus vaccines.

These lax testing requirements can save vaccine manufacturers tens of millions of dollars. That’s one of the reasons for the “gold rush” that has multiplied vaccines from three, when I was a boy, to the 50 plus vaccines that children typically receive today.

There are other compelling reasons why vaccines have become Pharma’s irresistible new profit and growth vehicle. For example, manufacturers of the 50 plus vaccines on CDC’s childhood schedule enjoy what has become a trapped audience of 74 million child consumers who are effectively compelled to purchase an expensive product, sparing vaccine makers additional millions in advertising and marketing costs.

But the biggest economic boon to vaccine makers has been the National Childhood Vaccine Injury Act (NCVIA). In 1986, Congress awash in pharmaceutical dollars—Big Pharma is, by far, the top Capitol Hill lobbying group—passed NCVIA giving pharmaceutical companies what amounts to blanket immunity from liability for any injury caused by vaccines. No matter how toxic the ingredients, how negligent the manufacturer or how grievous the harm, vaccine-injured children cannot sue a vaccine company. That extraordinary law eliminated a principal cost associated with making other drugs and left the industry with little economic incentive to make vaccines safe. It also removed lawyers, judges and courts from their traditional roles as guardians of vaccine safety. Since the law’s passage, industry revenues have sky-rocketed from $1 billion to $44 billion.

The absence of critical attention to this exploding industry by liberal online sites is particularly troubling since pharma, using strategic investments, has effectively sidelined, not just Congress, lawyers and courts, but virtually all of our democracy’s usual public health sentinels. Pervasive financial entanglements with vaccine makers and the other alchemies of agency capture have transformed the FDA and CDC into industry sock puppets.

Strong economic drivers—pharmaceutical companies are the biggest network advertisers—discourage mainstream media outlets from criticizing vaccine manufacturers. A network president once told me he would fire any of his news show hosts who allowed me to talk about vaccine safety on air. “Our news division,” he explained, “gets up to 70% of ad revenues from pharma in non-election years.” Furthermore, liberal activists including environmental, human rights, public health and children’s advocates also steer clear of vaccine safety discussions. On other core issues like toxics, guns and cigarettes, the CDC has a long record of friendly collaboration with these advocates who have thereby acquired a knee-jerk impulse to protect the agency from outside criticism.

In this vacuum, online liberal news sites are the last remaining barrier to protect children from corporate greed, yet they have become self-appointed arbiters against exposing the public to negative information about vaccine manufacturers and regulators. Liberal voices are not just sidelined, they are subsumed in the orthodoxy that all vaccines are always good for all people—and the more the better. Working with Pharma reps and their tame politicians, liberal news reporters and columnists across America are laboring in nearly every state to make the CDC vaccine schedule compulsory for children and to eliminate religious, philosophical and even medical exemptions.

As a result, the government/Big Pharma combination has gained unprecedented power to override parental consent and force otherwise healthy children, and other unwilling consumers, to undergo compulsory vaccinations, a shocking advance along the road to a corporate totalitarianism which seeks absolute control, even of our bodies. Keep in mind that there is no authentic dispute that vaccination is a risky medical intervention. It was the wave of lawsuits arising from injuries suffered from the Diphtheria/Tetanus/Pertussis (DTP) vaccine in the 1980s, that caused Congress to pass the NCVIA bestowing immunity on the pharmaceutical industry, which threatened, otherwise, to stop making vaccines. In upholding that law, the Supreme Court declared NCVIA justified because “vaccines are unavoidably unsafe.” Since then, the Federal Vaccine Court, created by NCVIA, has paid out $3.8 billion to vaccine-injured individuals. That number dramatically understates the true gravity of the harm. A Department of Health and Human Services funded report acknowledges that “fewer than 1% of vaccine adverse events are reported.”

Supporting a law that forces Americans to relinquish control of their bodies to a corporate/state behemoth is an odd posture for liberals, who once championed the precept of “informed consent,” as the mainstay of the Nuremberg Code and the declarations of Helsinki and Geneva which protect individuals against all coerced medical interventions.

Science suggests that we might have made a big mistake by not aggressively safety testing our mandatory vaccines. Chronic diseases like ADHD, asthma, autoimmune diseases and allergies now affect 54 percent of our children, up from 12.6 percent in 1988, the year NCVIA took effect. And those data measure only the injuries characterized in digital medical records. Health advocates warn that we may be missing subtler injuries like widespread losses in reading and IQ and in executive and behavioral functions.

The suspicion that the neurotoxins in vaccines may be negatively affecting a generation is not wild speculation. Numerous studies point to the once ubiquitous use of leaded gasoline as the cause of widespread IQ loss and violence that bedeviled the generations from the 1960s-1980s.  Is it not possible that dramatically increased infant exposures to aluminum and ethyl mercury—a far more potent neurotoxin than lead—might be significantly debilitating the post NCVIA generation?

The CDC claims that the cause of the sudden explosion in neurodevelopmental disorders, autoimmune illnesses and food allergies that began in the late 1980s, is a mystery. However, vaccine court awards, manufacturers’ package inserts and reams of peer-reviewed science all recognize that many of the chronic diseases that suddenly became epidemic in our children following the passage of NCVIA can be caused by vaccines or their ingredients.

The Institute of Medicine (now the National Academy of Medicine), the ultimate arbiter of federal vaccine safety science, has listed 155 diseases potentially associated with vaccination and scolded the CDC for failing to study 134 of them. School nurses who have spent decades in their jobs say they are seeing the sickest generation in history. The epidemic has not proven a problem for the vaccine industry. On the back end of the chronic disease explosion, vaccine companies like Merck are making a killing on the EpiPens, antidepressants, stimulants, asthma inhalers and anti-seizure drugs.

Instead of demanding blue-ribbon safety science and encouraging honest, open and responsible debate on the science, liberal blogs shut down discussion on this key public health and civil rights issue, and silence critics, treating faith in vaccines as a religion; the heresy of questioning dogma meets with anathema and excommunication.

The core of liberalism is a healthy skepticism toward government and business. So why do vaccines get a mulligan?

Robert F. Kennedy Jr. is a longtime environmental campaigner and author of American Values: Lessons I Learned From My Family (HarperCollins) and Crimes Against Nature: How George W. Bush and His Corporate Pals Are Plundering the Country and Hijacking Our Democracy. Follow him on Twitter: @RobertKennedyJr

April 12, 2020 Posted by | Corruption, Deception, Mainstream Media, Warmongering, Science and Pseudo-Science | | Leave a comment

COVID-19 and Vitamin D: Could We Be Missing Something Simple?

By Katie Weisman and the Children’s Health Defense Team | April 7, 2020

Introduction

Briefly, the literature on Vitamin D’s role in immune health has exploded in the past 10 years, particularly in relation to viral infections and autoimmune disorders. Approximately 80% of the literature is new in the past decade and much of it has been published overseas. There are studies showing that Vitamin D sufficiency is important to reduce mortality in ventilated patients. There is a large and growing literature on Vitamin D’s role in preventing viral infections and reducing their severity.

The populations at highest risk of severe cases of COVID-19 (the elderly and those with underlying health conditions) and the timing of the outbreak (end of winter in the Northern Hemisphere when population Vitamin D levels are typically lowest) are consistent with deficient Vitamin D status being a risk factor for COVID-19. The relatively small percentage of infections in children may reflect children’s higher milk consumption since milk is fortified with Vitamins A and D. Vitamin D is both a vitamin and a steroid hormone with hundreds of roles in our bodies.

A 2018 study based on NHANES data from 2001-2010 found that 28.9% of American adults were Vitamin D deficient (serum  25(OH)D<20ng/ml) and an additional 41.4% of American adults were Vitamin D insufficient (serum 25(OH)D between 20ng/ml and 30ng/ml). Americans who were black, less-educated, poor, obese, current smokers, physically inactive or infrequently consumed milk had higher prevalence of Vitamin D deficiency. Those with intestinal disorders (Crohn’s or celiac) that reduce dietary uptake of Vitamin D and those with liver or kidney diseases that may reduce the body’s conversion of Vitamin D to its active form may also be at increased risk of deficiency regardless of age. Vitamin D is a fat-soluble steroid hormone that regulates over 200 genes in the human body.

Questions that need answers

Based on the breadth of the research on Vitamin D in acute respiratory disorders and the many viral infections in which Vitamin D status plays a role, the following questions need to be answered:

  • Are hospitalized COVID-19 patients Vitamin D deficient (serum 25(OH)D levels < 20ng/ml) or insufficient (levels between 20ng/ml and 30ng/ml)?
  • Are hospitalized COVID-19 patients more Vitamin D deficient than would be expected in matched controls?
  • Are hospitalized COVID-19 patients who need intensive care more Vitamin D deficient?
  • Does giving high-dose Vitamin D to COVID-19 patients reduce their need for mechanical ventilation and/or reduce the amount of time that they require mechanical ventilation?
  • Does giving high-dose Vitamin D to health-care workers reduce their risk of COVID-19?
  • If Vitamin D deficiency is found in severe COVID-19 patients, what recommendation should be made to the general public, particularly those who are quarantined and/or fighting infections at home?

While only time and studies will give us definitive answers to these questions, Vitamin D testing is widely available, supplements are inexpensive and in a COVID-19 critical care setting we should consider anything that might reduce the number of cases, hospitalizations and deaths. Even a 10% reduction in one of these metrics would have a major impact.

The literature supports the importance of Vitamin D sufficiency

There are studies suggesting that sufficient Vitamin D reduces the risk of acute respiratory infections. Also, the literature supports the importance of Vitamin D sufficiency in reducing morbidity and mortality in critical care settings. This is a sample of the literature.

A 2017 article in the BMJ states the following: “25 eligible randomized controlled trials (total 11 321 participants, aged 0 to 95 years) were identified… Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants (adjusted odds ratio 0.88, 95% confidence interval 0.81 to 0.96; P for heterogeneity <0.001).” The protective effects were greatest in those who were deficient (serum levels <25 nmol/L = 10ng/ml) and in those who took Vitamin D regularly (on a daily or weekly basis) compared to large bolus doses.

Another 2018 review of the literature specifically in intensive care settings suggests that the non-significant results in some large trials of Vitamin D supplementation are likely the result of including subjects who are Vitamin D sufficient in the trials and not excluding Vitamin D supplements in the control groups. The authors are clear that “three different meta-analyses confirm that patients with low vitamin D status have a longer ICU stay and increased morbidity and mortality” and that “this hormone plays an important pleiotropic (having more than one effect) role in the setting of critical illness and may support recovery from severe acute illness.”

A small 2019 Iranian study recommended larger follow-up studies after randomizing 44 mechanically ventilated adult patients to 300,000 IU of Vitamin D vs. placebo. The study found a significant reduction in mortality (61.1% vs. 36.3%) and a non-significant 10-day reduction in time on the ventilator.

In a 2018 follow-up pilot study they found that in critically ill, ventilated patients, with Vitamin D deficiency and anemia, high-dose Vitamin D increased hemoglobin.

Additionally, a research group at Emory published a 2016 pilot study showing that high-dose Vitamin D decreased hospital length of stay in ventilated ICU patients. In a 2018 follow-up pilot study they found that in critically ill, ventilated patients, with Vitamin D deficiency and anemia, high-dose Vitamin D increased hemoglobin.

A 2017 study found that “Monthly high-dose vitamin D3 supplementation reduced the incidence of ARI (acute respiratory infections) in older long-term care residents but was associated with a higher rate of falls without an increase in fractures.”

A 2015 study in Thorax found that Vitamin D deficiency was common in patients who developed acute respiratory distress syndrome after esophagectomy.

A 2018 study in the Indian Journal of Anesthesia reported no significant results in mechanically respirated patients based on Vitamin D deficiency vs. sufficiency at admission, but this was likely due to small sample size. The trends for days in the ICU, days on mechanical ventilation, days to spontaneous breathing trial and 30-day mortality were all more favorable in the group with sufficient Vitamin D.

In another 2018 Iranian study of 46 patients with Vitamin D deficiency and Ventilator-Associated Pneumonia, a single dose of 300,000 IU of Vitamin D compared to placebo significantly reduced serum levels of IL-6 and significantly reduced mortality.  IL-6 is a cytokine that is typically elevated in acute respiratory distress syndrome.

Unlike the above studies, a large 2014 Austrian study of 492 critically ill patients with Vitamin D deficiency did not find significant results with Vitamin D supplementation for most of its outcome measures. The only significant result was decreased hospital mortality in the severely Vitamin D deficient subgroup.  However, this study population included surgical, neurological and medical patients and it is possible that Vitamin D is only relevant for respiratory infections. Also, this study reported no serious adverse events using very high doses of Vitamin D in a critically ill population.

A 2017 rat study showed that pretreatment with calcitriol (the active form of Vitamin D) reduced lipopolysaccharide-induced acute lung injury by modulating the renin-angiotensin system. ACE and ACE2 are part of this system and ACE2 is the binding site of SARS-CoV2 on cells.  There is an unresolved ongoing debate on whether angiotensin converting enzyme inhibitors (ACE inhibitors) used to treat blood pressure and heart conditions increase or decrease the risk of SARS-CoV2 infection.  How Vitamin D deficiency might fit into this discussion is an open question.

Interestingly, a 2018 case-control study of 532 Japanese workers found that in a subgroup of participants without vaccination, vitamin D sufficiency was associated with a significantly lower risk of influenza.

Research on Vitamin D in other viral infections

Vitamin D deficiency has been studied in many viruses and, generally, sufficient Vitamin D levels lead to lower rates of infection and less severe cases. This research is a combination of in vitro and in vivo studies.  There is no specific literature on coronaviruses so we looked for research on Vitamin D in other viral infections including Influenza, HIV, Dengue, Epstein Barr, Hepatitis B and Hepatitis C. Some examples follow:

A 2018 Chinese trial of two different doses of Vitamin D in 400 infants showed significantly lower risk of influenza A, reduced viral load and reduced duration of symptoms in the group on the higher dose.  A similar 2010 study in Japanese school children found that 1200 IU/day of Vitamin D reduced Influenza A infections from 18.6% in the placebo group to 10.8% in the supplemented group. The supplemented children with asthma also had a reduced risk of asthma attacks.  Interestingly, a 2018 case-control study of 532 Japanese workers found that “In a subgroup of participants without vaccination, vitamin D sufficiency (≥30 ng/mL) was associated with a significantly lower risk of influenza (odds ratio 0.14; 95% confidence interval 0.03-0.74)”.

A 2018 study of youth with HIV showed that high-dose Vitamin D attenuated immune activation and exhaustion from anti-retroviral therapy. A 2016 study of 466 South African infants (half HIV-infected) found that low Vitamin D and SNPs on certain genes increased the risk of tuberculosis and death. A 2018 review of Vitamin D in HIV infection states, “High levels of VitD and VDR expression are also associated with natural resistance to HIV-1 infection. Conversely, VitD deficiency is linked to more inflammation and immune activation, low peripheral blood CD4+ T-cells, faster progression of HIV disease, and shorter survival time in HIV-infected patients.”

A small 2020 study of healthy patients showed that higher dose Vitamin D supplementation reduced susceptibility to DENV-2 (dengue) infection in blood cells. A 2017 study of human monocyte-derived macrophages found that “DENV bound less efficiently to vitamin D3-differentiated macrophages, leading to lower infection”.

The situation with Vitamin D deficiency and Epstein-Barr virus infection in Relapsing/Remitting Multiple Sclerosis (RRMS) is more nuanced. While each is an independent risk factor for RRMS, recent studies have found that high-dose Vitamin D supplementation resulted in significantly lower antibody levels to EBNA-1. In this case the lower antibody levels lead to lower risk of relapse and lower risk of new lesions on MRI.

A 2019 meta-analysis of studies of Vitamin D status in chronic Hepatitis B infections found that “Vitamin D levels were lower in CHB patients and inversely correlated with viral load”. A 2018 Israeli study found that Hepatitis B transfected liver cancer cells actually downregulate Vitamin D receptors to allow the virus to replicate.

In a 2012 Israeli study, the addition of Vitamin D to standard anti-viral therapy in patients with chronic Hepatitis C infections improved viral response. A 2015 study of Egyptian children with Hepatitis C found that cases treated with Vitamin D along with antivirals showed significantly higher “early and sustained virological response” compared to controls.

One additional factor should be considered. Single nucleotide polymorphisms that affect Vitamin D Receptor function and metabolism of Vitamin D to its active form affect sufficiency, so identifying patients with those polymorphisms will help identify those at greater risk for Vitamin D deficiency. There is a growing literature on these genetic factors as well.

Last week, former CDC Director, Dr. Tom Frieden, suggested that Vitamin D might decrease coronavirus infections. We hope this article will convince doctors and researchers to take a closer look at Vitamin D as a potential preventative and therapeutic option. As we stated in our recent video, we think that scarce resources should be focused on treatment versus a vaccine that may never materialize.

Last, a caveat

This is not medical advice and you should not take high doses of Vitamin D without checking with your doctor, particularly if you have any underlying health conditions. Vitamin D does have potential toxicity at high levels including hypercalcemia and kidney stones. A daily dose of 800 IU – 2000 IU of Vitamin D is generally regarded as safe and will produce sufficiency in most people, but more is not necessarily better. NIH’s information on Vitamin D dosing and drug interactions can be found here.

April 11, 2020 Posted by | Science and Pseudo-Science, Timeless or most popular | Leave a comment

Vitamin D and immunity

Dr. John Campbell | March 9, 2020

Vitimin D https://news.harvard.edu/gazette/stor…

https://www.bmj.com/content/356/bmj.i…

https://cks.nice.org.uk/vitamin-d-def…

April 10, 2020 Posted by | Science and Pseudo-Science, Timeless or most popular | Leave a comment